Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12962557 | 0.85 | HPGD (0.57) | HPGDPOLBKMT2AMAPTMEN1 | |
| SCHEMBL24718226 | 0.83 | CNR1 (0.48) | CNR1CNR2KMT2AMAPTMEN1 | |
| SCHEMBL30798372 | 0.83 | CNR1 (0.48) | CNR1CNR2KMT2AMAPTMEN1 | |
| SCHEMBL14749180 | 0.81 | RAB9A (0.53) | POLBCNR1CNR2KMT2AMAPT | |
| SCHEMBL11833693 | 0.80 | LCK (0.53) | POLBCNR1CNR2KMT2AMAPT | |
| SCHEMBL9778317 | 0.79 | HPGD (0.63) | HPGDPOLBKMT2AMAPTMEN1 | |
| SCHEMBL7502111 | 0.77 | HPGD (0.61) | HPGDPOLBKMT2AMAPTMEN1 | |
| SCHEMBL12897088 | 0.76 | CA1 (0.59) | CNR1CNR2KMT2AMAPTMEN1 | |
| SCHEMBL11838628 | 0.76 | RAB9A (0.48) | HPGDKMT2AMAPTMEN1NPC1 | |
| SCHEMBL26333926 | 0.76 | HPGD (0.59) | HPGDPOLBKMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3985889-A | 1,3-DIHYDROSPIRO(ISOBENZOFURAN); ANALGETIC AGENTS | AMERICAN HOECHST CORPORATION (US) | 1976-10-12 | — | — | US | disclosed |
| US-3962259-A | TRANQUILIZERS, ANALGETIC AGENTS | AMERICAN HOECHST CORPORATION (US) | 1976-06-08 | — | — | US | disclosed |