Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | SLC10A2 | Q12908 | 12/20 | 0.37 |
| ▸ | CTSD | P07339 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14559691 | 1.00 | NR1H4 (0.55) | NR1H4SLC10A2CTSD | |
| SCHEMBL3851490 | 1.00 | NR1H4 (0.55) | NR1H4SLC10A2CTSD | |
| Ammonia Solution, Strong SCHEMBL5223721 | 0.99 | NR1H4 (0.55) | NR1H4SLC10A2CTSD | |
| SCHEMBL3459109 | 0.97 | NR1H4 (0.56) | NR1H4SLC10A2CTSD | |
| SCHEMBL1183437 | 0.97 | NR1H4 (0.56) | NR1H4SLC10A2CTSD | |
| SCHEMBL5226167 | 0.97 | NR1H4 (0.56) | NR1H4SLC10A2CTSD | |
| Ammonia Solution, Strong SCHEMBL5225513 | 0.97 | NR1H4 (0.56) | NR1H4SLC10A2CTSD | |
| SCHEMBL919120 | 0.96 | NR1H4 (0.61) | NR1H4SLC10A2 | |
| SCHEMBL14559696 | 0.94 | NR1H4 (0.54) | NR1H4SLC10A2CTSD | |
| SCHEMBL919016 | 0.94 | NR1H4 (0.62) | NR1H4SLC10A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1894564-B1 | Use of an IBAT inhibitor for the treatment or prophylaxis of constipation | ALBIREO AB (SE) | 2011-06-22 | — | — | EP | claimed |
| EP-1458677-B1 | 3-PHENYL-2-ARYLALKYLTHIOPROPIONIC ACID DERIVATIVES AS SELECTIVE AGONISTS OF PPAR-ALPHA | ASTRAZENECA AB (SE) | 2009-04-15 | — | — | EP | claimed |
| US-7514421-B2 | Use of an IBAT inhibitor for the treatment of constipation | ALBIREO AB (SE) | 2009-04-07 | — | — | US | claimed |
| US-7514471-B2 | Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor α (PPAR) | ASTRAZENECA AB (SE) | 2009-04-07 | — | — | US | claimed |
| EP-1894564-A2 | Use of an ibat inhibitor for the treatment of prophylaxis of constipation | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | claimed |
| US-7276539-B2 | 3-Phenyl-2-arylalkylthiopropionic acid derivatives as selective agonists of ppar-alpha | ASTRAZENECA AB (SE) | 2007-10-02 | — | — | US | claimed |
| US-7256307-B2 | Substituted phenypropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor α(PPAR) | ASTRAZENECA AB (SE) | 2007-08-14 | — | — | US | claimed |
| EP-1458672-B1 | SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVES AS AGONISTS TO HUMAN PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA(PPAR) | ASTRAZENECA AB (SE) | 2007-05-30 | — | — | EP | claimed |
| EP-1345918-B1 | 1,5 BENZOTHIAZEPINES AND THEIR USE AS ANTIHYPERLIPIDEMICS | ASTRAZENECA AB (SE) | 2007-04-18 | — | — | EP | claimed |
| EP-1458673-B1 | SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVES AS AGONISTS TO HUMAN PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPAR) | ASTRAZENECA AB (SE) | 2006-09-06 | — | — | EP | claimed |
| US-20050171204-A1 | Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar) | ASTRAZENECA AB (SE) | 2005-08-04 | — | — | US | claimed |
| US-20050131068-A1 | Therapeutic agents | ASTRAZENECA AB (SE) | 2005-06-16 | — | — | US | claimed |
| EP-1539120-A1 | COMBINATION OF AN IBAT INHIBITOR AND A METAL SALT FOR THE TREATMENT OF DIARRHOEA | Astrazeneca AB (SE) | 2005-06-15 | — | — | EP | claimed |
| US-20050113362-A1 | Substituted phenypropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar) | ASTRAZENECA AB R & D HEADQUARTERS - GLOBAL IINTELLECTUAL PROPERT (SE) | 2005-05-26 | — | — | US | claimed |
| EP-1458673-A1 | SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVES AS AGONISTS TO HUMAN PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPAR) | Astrazeneca AB (SE) | 2004-09-22 | — | — | EP | claimed |
| EP-1458672-A1 | SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVES AS AGONISTS TO HUMAN PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA(PPAR) | AstraZeneca AB (SE) | 2004-09-22 | — | — | EP | claimed |
| US-20040067933-A1 | Chemical compounds | ELOBIX AB (SE) | 2004-04-08 | — | — | US | claimed |
| WO-2004006899-A1 | COMBINATION OF AN IBAT INHIBITOR AND A METAL SALT FOR THE TREATMENT OF DIARRHOEA | ASTRAZENECA AB (SE) | 2004-01-22 | — | — | WO | claimed |
| WO-2003051822-A1 | SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVES AS AGONISTS TO HUMAN PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPAR) | ASTRAZENECA AB (SE) | 2003-06-26 | — | — | WO | claimed |
| WO-2003051821-A1 | SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVES AS AGONISTS TO HUMAN PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPAR) | ASTRAZENECA AB (SE) | 2003-06-26 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050131068-A1 | Therapeutic agents | GPR119, INSR, LIPA | NR1H4 94/4885SLC10A2 175/4885CTSD 2273/4885 |
| US-20040067933-A1 | Chemical compounds | SLC10A2, SLC10A1, ABCB11 | NR1H4 7/4885SLC10A2 1/4885CTSD 2456/4885 |
| US-20050113362-A1 | Substituted phenypropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar) | PPARA, PPARD, PPARG | NR1H4 33/4885SLC10A2 434/4885CTSD 3213/4885 |
| US-20050171204-A1 | Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar) | PPARA, PPARD, PPARG | NR1H4 46/4885SLC10A2 209/4885CTSD 3453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.