Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11847324 | 0.80 | ADRB2 (0.64) | KDM4ELMNAALDH1A1ADRB2ADRB1 | |
| SCHEMBL11857575 | 0.76 | KDM4E (0.43) | KDM4ELMNAL3MBTL1MAPTTHRB | |
| SCHEMBL8415057 | 0.74 | KDM4E (0.62) | KDM4ELMNAL3MBTL1ADRB2 | |
| SCHEMBL8417780 | 0.70 | GABRA1 (0.51) | LMNAL3MBTL1MAPTALDH1A1POLB | |
| SCHEMBL2841495 | 0.70 | LMNA (0.47) | LMNAL3MBTL1MAPTALDH1A1TDP1 | |
| SCHEMBL2849234 | 0.69 | L3MBTL1 (0.49) | KDM4ELMNAL3MBTL1MAPTALDH1A1 | |
| SCHEMBL11857582 | 0.69 | KDM4E (0.40) | KDM4ELMNAL3MBTL1MAPTTHRB | |
| SCHEMBL5630614 | 0.67 | ADRB2 (0.42) | KDM4EALDH1A1ADRB2ADRB1ADRB3 | |
| SCHEMBL2838981 | 0.66 | L3MBTL1 (0.49) | KDM4ELMNAL3MBTL1MAPTALDH1A1 | |
| SCHEMBL6449391 | 0.66 | KDM4E (0.47) | KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3996382-A | Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases | AKTIEBOLAGET HASSLE (SW) | 1976-12-07 | — | — | US | claimed |