Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | RPA1 | P27694 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2320824 | 0.88 | ALDH1A1 (0.59) | PPP1CAKMT2ARPA1MAPTPOLB | |
| SCHEMBL11860723 | 0.87 | POLB (0.61) | SMN1; SMN2PPP1CAKMT2AMEN1RPA1 | |
| SCHEMBL11857760 | 0.84 | MALT1 (0.50) | SMN1; SMN2PPP1CAKMT2AMEN1RPA1 | |
| SCHEMBL28248773 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2PPP1CAKMT2AMEN1RPA1 | |
| SCHEMBL2322024 | 0.77 | THRB (0.50) | PPP1CAKMT2AMEN1RPA1CFTR | |
| SCHEMBL15682943 | 0.77 | MAPT (0.50) | KMT2AMEN1RPA1MAPTPOLB | |
| SCHEMBL14728132 | 0.77 | SMN1; SMN2 (0.86) | SMN1; SMN2PPP1CAKMT2AMEN1RPA1 | |
| SCHEMBL24885858 | 0.76 | SMN1; SMN2 (0.59) | SMN1; SMN2PPP1CAKMT2AMEN1RPA1 | |
| SCHEMBL31420389 | 0.76 | POLB (0.63) | KMT2AMEN1MAPTPOLBALDH1A1 | |
| SCHEMBL1514335 | 0.75 | RPA1 (0.80) | SMN1; SMN2PPP1CAKMT2AMEN1RPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3953467-A | ANALYGESICS, ANTIINFLAMMATORY AGENTS | MARUKO SEIYAKU CO., LTD. (JA) | 1976-04-27 | — | — | US | disclosed |