Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.65 |
| ▸ | CA2 | P00918 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | BLM | P54132 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.51 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.51 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | WRN | Q14191 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565680 | 0.78 | MAPT (0.60) | CA1CA2HTTSMN1; SMN2MEN1 | |
| SCHEMBL11871659 | 0.78 | HTT (0.57) | CA1CA2HTTSMN1; SMN2MEN1 | |
| SCHEMBL8569537 | 0.74 | HTT (1.00) | CA1CA2HTTSMN1; SMN2MEN1 | |
| SCHEMBL8561964 | 0.73 | HTT (0.75) | CA1CA2HTTSMN1; SMN2MEN1 | |
| SCHEMBL8559872 | 0.72 | HTT (0.73) | CA1CA2HTTSMN1; SMN2MEN1 | |
| SCHEMBL8563911 | 0.71 | RAB9A (0.74) | CA1CA2HTTSMN1; SMN2MEN1 | |
| SCHEMBL8777974 | 0.70 | EPHX2 (0.80) | HTTMEN1KMT2AALDH1A1EPHX2 | |
| SCHEMBL8563248 | 0.70 | HTT (0.65) | CA1CA2HTTSMN1; SMN2MEN1 | |
| SCHEMBL11875081 | 0.69 | BLM (0.80) | CA1CA2HTTSMN1; SMN2MEN1 | |
| SCHEMBL8561139 | 0.69 | HTT (0.67) | CA1CA2HTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3990879-A | SUBSTITUTED 1-THIADIAZOLYL-3-ARYL-UREAS | ELI LILLY AND COMPANY (US) | 1976-11-09 | — | — | US | disclosed |