Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | HTT | P42858 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | BLM | P54132 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.52 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.52 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487336 | 0.80 | MAPT (0.60) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL11871659 | 0.78 | HTT (0.57) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL11868024 | 0.78 | CA1 (0.65) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL3467894 | 0.77 | MEN1 (0.62) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL3467177 | 0.76 | RAB9A (0.64) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL8569537 | 0.75 | HTT (1.00) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL8561964 | 0.74 | HTT (0.75) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL10800511 | 0.73 | RAB9A (0.57) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL8559872 | 0.73 | HTT (0.73) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL3467864 | 0.73 | MEN1 (0.59) | MAPTMEN1KMT2AHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-3990879-A | SUBSTITUTED 1-THIADIAZOLYL-3-ARYL-UREAS | ELI LILLY AND COMPANY (US) | 1976-11-09 | — | — | US | disclosed |