Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.39 |
| ▸ | NSD2 | O96028 | 3/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 5/20 | 0.36 |
| ▸ | CDC25B | P30305 | 3/20 | 0.36 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19205274 | 0.75 | TDP2 (0.30) | TDP2NSD2PAX8TDP1ABL1 | |
| SCHEMBL1187365 | 0.70 | TDP1 (0.44) | TDP2NSD2PAX8TDP1ABL1 | |
| SCHEMBL300666 | 0.70 | TDP2 (0.46) | TDP2NSD2PAX8TDP1ABL1 | |
| SCHEMBL28654085 | 0.69 | NAPRT (0.31) | — | |
| SCHEMBL388585 | 0.67 | TDP2 (0.48) | TDP2NSD2PAX8TDP1ABL1 | |
| SCHEMBL32689420 | 0.65 | TDP1 (0.39) | TDP2NSD2PAX8TDP1ABL1 | |
| SCHEMBL32689421 | 0.63 | TDP1 (0.38) | TDP2NSD2PAX8TDP1ABL1 | |
| SCHEMBL1895059 | 0.61 | TDP1 (0.37) | TDP2NSD2PAX8TDP1ABL1 | |
| SCHEMBL31288011 | 0.61 | TDP1 (0.37) | TDP2NSD2PAX8TDP1ABL1 | |
| SCHEMBL2065716 | 0.60 | S100A4 (0.45) | TDP2NSD2PAX8TDP1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8471006-B2 | Coupling agents for peptide synthesis | UNIVERSITY OF MASSACHUSETTS (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120277428-A1 | NEW COUPLING AGENTS FOR PEPTIDE SYNTHESIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-11-01 | — | — | US | disclosed |
| US-8217169-B2 | Coupling agents for peptide synthesis | UNIVERSITY OF MASSACHUSETTS (US) | 2012-07-10 | — | — | US | disclosed |
| US-20110028720-A1 | New Coupling Agents for Peptide Synthesis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-02-03 | — | — | US | disclosed |
| US-7812158-B2 | Coupling agents for peptide synthesis | UNIVERSITY OF MASSACHUSETTS (US) | 2010-10-12 | — | — | US | disclosed |
| EP-1687318-A4 | NEW COUPLING AGENTS FOR PEPTIDE SYNTHESIS | UNIV MASSACHUSETTS (US) | 2009-01-07 | — | — | EP | disclosed |
| US-20070112196-A1 | New coupling agents for peptide synthesis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-05-17 | — | — | US | disclosed |
| EP-1687318-A2 | NEW COUPLING AGENTS FOR PEPTIDE SYNTHESIS | University of Massachusetts (US) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005042562-A2 | NEW COUPLING AGENTS FOR PEPTIDE SYNTHESIS | THE UNIVERSITY OF MASSACHUSETTS (US) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277428-A1 | NEW COUPLING AGENTS FOR PEPTIDE SYNTHESIS | NGLY1, NPPA, VIP | TDP2 4675/4885NSD2 4234/4885PAX8 3679/4885 |
| US-20070112196-A1 | New coupling agents for peptide synthesis | NGLY1, NPPA, VIP | TDP2 4595/4885NSD2 4455/4885PAX8 3649/4885 |
| US-20110028720-A1 | New Coupling Agents for Peptide Synthesis | NGLY1, NPPA, VIP | TDP2 4675/4885NSD2 4234/4885PAX8 3679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.