Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.35 |
| ▸ | USP1 | O94782 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11842534 | 0.79 | TSHR (0.50) | ALDH1A1HPGDUTS2RUSP1LMNA | |
| SCHEMBL4595659 | 0.72 | CES1 (0.50) | ALDH1A1HPGDCSNK2BCSNK2A1LMNA | |
| SCHEMBL11873522 | 0.71 | TRPA1 (0.40) | — | |
| SCHEMBL11871825 | 0.68 | CHRM1 (0.53) | ALDH1A1LMNAL3MBTL1SMN1; SMN2HTT | |
| SCHEMBL11881664 | 0.68 | P2RX7 (0.51) | HPGDLMNAL3MBTL1MEN1CYP2C19 | |
| SCHEMBL11800738 | 0.68 | ALDH1A1 (0.40) | ALDH1A1HPGDUSP1CYP2D6 | |
| SCHEMBL6925572 | 0.67 | LMNA (0.58) | ALDH1A1HPGDCSNK2BCSNK2A1LMNA | |
| SCHEMBL29393294 | 0.67 | LMNA (0.58) | ALDH1A1HPGDCSNK2BCSNK2A1LMNA | |
| SCHEMBL607042 | 0.67 | LMNA (0.58) | ALDH1A1HPGDCSNK2BCSNK2A1LMNA | |
| SCHEMBL11852580 | 0.64 | TSHR (0.54) | ALDH1A1LMNACYP2D6MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3984556-A | Alkyl-substituted-tricyclic quinazolinones for lowering blood pressure | SANDOZ, INC. (US) | 1976-10-05 | — | — | US | disclosed |
| US-3982000-A | Alkyl-substituted-tricyclic quinazolinones as bronchodilators | SANDOZ, INC. (US) | 1976-09-21 | — | — | US | disclosed |