Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SCN4A | P35499 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.37 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.37 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523395 | 0.78 | HPGD (0.46) | PARP1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL8143932 | 0.76 | NPC1 (0.44) | KDM4EHPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8156271 | 0.73 | HPGD (0.50) | KDM4EHPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3689757 | 0.71 | KDM4E (0.40) | PARP1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL11751025 | 0.71 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1BCHEACHEKMT2A | |
| SCHEMBL31707307 | 0.71 | HPGD (0.40) | PARP1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL103176 | 0.71 | KDM4E (0.55) | KDM4EHPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL20818702 | 0.70 | DGAT1 (0.43) | KDM4EHPGDSMN1; SMN2MAPTALDH1A1 | |
| Water SCHEMBL994995 | 0.69 | KDM4E (0.52) | KDM4EHPGDSMN1; SMN2MAPTALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL2472975 | 0.69 | KDM4E (0.52) | KDM4EHPGDSMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668157-A1 | PROTEASE ACTIVATED RECEPTOR 2 (PAR2) ANTAGONISTS | Proximagen Limited (GB) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101453-A1 | PROTEASE ACTIVATED RECEPTOR 2 (PAR2) ANTAGONISTS | PROXIMAGEN LTD. (GB) | 2012-08-02 | — | — | WO | disclosed |
| US-3915979-A | Preparation of benzotriazole-2-carboxamides | SMITHKLINE BECKMAN CORPORATION | 1975-10-28 | — | — | US | disclosed |
| US-3915979-A | Preparation of benzotriazole-2-carboxamides | SMITHKLINE BECKMAN CORPORATION | 1975-10-28 | — | — | US | disclosed |