⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1188886 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL5433679 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL665689 | 0.97 | — | — | |
| SCHEMBL14964730 | 0.79 | — | — | |
| SCHEMBL16212361 | 0.79 | — | — | |
| SCHEMBL14971271 | 0.79 | — | — | |
| SCHEMBL16212586 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL16212468 | 0.76 | CCR5 (0.33) | — | |
| SCHEMBL56292 | 0.69 | — | — | |
| SCHEMBL11405642 | 0.67 | DRD2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217226-B1 | PEPTIDE DEFORMYLASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2015-07-22 | — | — | EP | disclosed |
| US-20130045962-A1 | PEPTIDE DEFORMYLASE INHIBITORS | GLAXOSMITHKLINE LLC | 2013-02-21 | — | — | US | disclosed |
| US-7893056-B2 | Peptide deformylase inhibitors | GLAXOSMITHKLINE LLC (US) | 2011-02-22 | — | — | US | disclosed |
| US-20090306066-A1 | PEPTIDE DEFORMYLASE INHIBITORS | GLAXOSMITHKLINE LLC | 2009-12-10 | — | — | US | disclosed |
| US-7547722-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2009-06-16 | — | — | US | disclosed |
| US-20080045517-A1 | 6H-THIENO[2,3-b]PYRROLE DERIVATIVES AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE (GNRH) | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | US | disclosed |
| US-7268158-B2 | 6H-THIENO [2,3-b]pyrrole derivatives as antagonists of gonadotropin releasing hormone (GnRH) | ASTRAZENECA AB (SE) | 2007-09-11 | — | — | US | disclosed |
| US-20070027145-A1 | Quinazoline derivatives as inhibitors of vegf receptor tyrosine kinases | ASTRAZENCA (SE) | 2007-02-01 | — | — | US | disclosed |
| US-20070027145-A1 | Quinazoline derivatives as inhibitors of vegf receptor tyrosine kinases | ASTRAZENCA (SE) | 2007-02-01 | — | — | US | disclosed |