Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 2/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.40 |
| ▸ | NOS2 | P35228 | 2/20 | 0.40 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20073632 | 0.95 | BACE1 (0.38) | BACE1NOS3NOS1NOS2ACMSD | |
| SCHEMBL20073769 | 0.91 | HDAC1 (0.38) | BACE1NOS3NOS1NOS2HDAC1 | |
| SCHEMBL20150185 | 0.83 | HTR1D (0.36) | HDAC1HDAC2EPHX2HTR1DHDAC3 | |
| SCHEMBL3985023 | 0.77 | BACE1 (0.51) | BACE1NOS3NOS1NOS2ACMSD | |
| SCHEMBL790114 | 0.77 | BACE1 (0.47) | BACE1NOS3NOS1NOS2ACMSD | |
| SCHEMBL15156130 | 0.75 | BACE1 (0.49) | BACE1ACMSDHDAC1HDAC2EPHX2 | |
| SCHEMBL25630463 | 0.74 | ALDH1A1 (0.45) | BACE1NOS3NOS1NOS2ACMSD | |
| SCHEMBL10627717 | 0.74 | BACE1 (0.49) | BACE1ACMSDHDAC1HDAC2EPHX2 | |
| SCHEMBL10887623 | 0.73 | ACMSD (0.38) | NOS3NOS1NOS2ACMSDHDAC2 | |
| SCHEMBL20975678 | 0.73 | BACE1 (0.47) | BACE1NOS3NOS1NOS2ACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668186-B1 | PHARMACEUTICAL COMPOSITION COMPRISING PYRIDONE DERIVATIVES | SK BIOPHARMACEUTICALS CO LTD (KR) | 2017-05-03 | — | — | EP | disclosed |
| US-8716309-B2 | Pharmaceutical composition comprising pyridone derivatives | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2014-05-06 | — | — | US | disclosed |
| EP-2668186-A1 | PHARMACEUTICAL COMPOSITION COMPRISING PYRIDONE DERIVATIVES | SK Biopharmaceuticals Co., Ltd. (KR) | 2013-12-04 | — | — | EP | disclosed |
| US-20130317059-A1 | PHARMACEUTICAL COMPOSITION COMPRISING PYRIDONE DERIVATIVES | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2013-11-28 | — | — | US | disclosed |
| WO-2012102580-A1 | PHARMACEUTICAL COMPOSITION COMPRISING PYRIDONE DERIVATIVES | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2012-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130317059-A1 | PHARMACEUTICAL COMPOSITION COMPRISING PYRIDONE DERIVATIVES | PLPBP, PDXK, PIR | BACE1 455/4885NOS3 3445/4885NOS1 3840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.