Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | PLAU | P00749 | 1/20 | 0.54 |
| ▸ | NOS1 | P29475 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | NOS3 | P29474 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11897674 | 1.00 | CES2 (0.54) | CES2CES1PLAUNOS1ALDH1A1 | |
| SCHEMBL7460429 | 0.93 | CES1 (0.54) | CES2CES1PLAUNOS1ALDH1A1 | |
| SCHEMBL5609313 | 0.83 | CES2 (0.58) | CES2CES1PLAUNOS1ALDH1A1 | |
| SCHEMBL18100425 | 0.82 | MEN1 (0.48) | CES2CES1PLAUNOS1ALDH1A1 | |
| SCHEMBL9423002 | 0.80 | RAB9A (0.52) | PLAUNOS1ALDH1A1LMNAMEN1 | |
| SCHEMBL9423004 | 0.80 | RAB9A (0.52) | PLAUNOS1ALDH1A1LMNAMEN1 | |
| SCHEMBL4869749 | 0.80 | PLAU (0.64) | CES2CES1PLAUNOS1ALDH1A1 | |
| SCHEMBL11126692 | 0.80 | NOS1 (0.62) | CES2CES1PLAUNOS1ALDH1A1 | |
| SCHEMBL4624494 | 0.78 | KMT2A (0.54) | CES2CES1PLAUNOS1ALDH1A1 | |
| SCHEMBL4624489 | 0.78 | KMT2A (0.54) | CES2CES1PLAUNOS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9604947-B2 | Substituted 5-imino-1,2,4-thiadiazoles that can be used to treat neurodegenerative diseases | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2017-03-28 | — | — | US | disclosed |
| US-20120225879-A1 | SUBSTITUTED 5-IMINO-1,2,4-THIADIAZOLES THAT CAN BE USED TO TREAT NEURODEGENERATIVE DISEASES | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFACAS ( CSIC) (ES) | 2012-09-06 | — | — | US | disclosed |
| EP-2484670-A1 | SUBSTITUTED 5-IMINO-1,2,4-THIADIAZOLES THAT CAN BE USED TO TREAT NEURODEGENERATIVE DISEASES | Consejo Superior de Investigaciones Cientificas (CSIC) (ES) | 2012-08-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225879-A1 | SUBSTITUTED 5-IMINO-1,2,4-THIADIAZOLES THAT CAN BE USED TO TREAT NEURODEGENERATIVE DISEASES | PDE7B, PDE7A, PARK7 | CES2 1234/4885CES1 645/4885PLAU 3851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.