Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | HPGD | P15428 | 4/20 | 0.69 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | CDH1 | P12830 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | PTPRA | P18433 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11902926 | 0.85 | ALDH1A1 (0.67) | ALDH1A1HPGDPTPN1MAPTRECQL | |
| SCHEMBL1179647 | 0.82 | ALDH1A1 (1.00) | ALDH1A1HPGDPTPN1MAPTRECQL | |
| SCHEMBL5620215 | 0.79 | PTPN1 (1.00) | ALDH1A1HPGDPTPN1MAPTRECQL | |
| SCHEMBL4398693 | 0.79 | PTPN1 (0.69) | ALDH1A1HPGDPTPN1MAPTRECQL | |
| SCHEMBL4791629 | 0.78 | ALDH1A1 (0.73) | ALDH1A1HPGDPTPN1MAPTRECQL | |
| SCHEMBL70042 | 0.77 | PTPN1 (0.76) | ALDH1A1HPGDPTPN1MAPTRECQL | |
| SCHEMBL29742857 | 0.77 | NR4A2 (0.50) | DHODH | |
| SCHEMBL17261697 | 0.76 | CDH1 (0.49) | ALDH1A1HPGDPTPN1MAPTRECQL | |
| SCHEMBL3759024 | 0.76 | ALDH1A1 (0.66) | ALDH1A1HPGDPTPN1 | |
| SCHEMBL27930829 | 0.76 | DHODH (0.49) | ALDH1A1LDHADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120202794-A1 | COMPOUNDS | PHARMASSET, INC. (US) | 2012-08-09 | — | — | US | disclosed |
| US-20120202794-A1 | COMPOUNDS | PHARMASSET, INC. (US) | 2012-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202794-A1 | COMPOUNDS | HAVCR2, MAVS, GOT2 | ALDH1A1 253/4885HPGD 2240/4885PTPN1 3220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.