Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | STAT1 | P42224 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.57 |
| ▸ | LDHA | P00338 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | CBFB | Q13951 | 3/20 | 0.51 |
| ▸ | RUNX1 | Q01196 | 4/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903458 | 0.90 | CYP11B1 (0.64) | KDM4EMAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL11903477 | 0.85 | TRPV1 (0.57) | KDM4EMAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL19970729 | 0.82 | NAMPT (0.49) | KDM4EMAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL4036018 | 0.81 | KIT (0.49) | KDM4EMAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL19970839 | 0.81 | KIT (0.49) | KDM4EMAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL5683118 | 0.81 | DGAT1 (0.73) | KDM4EMAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL11903464 | 0.79 | TRPV1 (0.60) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11903487 | 0.79 | CYP1A2 (0.54) | KDM4ERAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL10175464 | 0.79 | CYP11B1 (0.79) | KDM4EMAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL11903647 | 0.78 | TRPV1 (0.62) | KDM4EMAPTRAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293780-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | U.S. DEPARTMENT OF ENERGY (US) | 2012-10-23 | — | — | US | disclosed |
| US-8242284-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 2012-08-14 | — | — | US | disclosed |