Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.62 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.47 |
| ▸ | RUNX1 | Q01196 | 4/20 | 0.46 |
| ▸ | CBFB | Q13951 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903498 | 0.89 | TRPV1 (0.77) | TRPV1NPBWR1CHEK2RUNX1CBFB | |
| SCHEMBL11903647 | 0.89 | TRPV1 (0.62) | TRPV1NPBWR1CHEK2RUNX1CBFB | |
| SCHEMBL11903464 | 0.88 | TRPV1 (0.60) | TRPV1CHEK2RUNX1CBFBKDM4E | |
| SCHEMBL11903440 | 0.86 | TRPV1 (0.58) | TRPV1CHEK2RUNX1CBFBKDM4E | |
| SCHEMBL11903477 | 0.86 | TRPV1 (0.57) | TRPV1NPBWR1CHEK2RUNX1CBFB | |
| SCHEMBL11903531 | 0.86 | TRPV1 (0.58) | TRPV1NPBWR1CHEK2RUNX1CBFB | |
| SCHEMBL11903515 | 0.86 | TRPV1 (0.58) | TRPV1CHEK2RUNX1CBFBKDM4E | |
| SCHEMBL11903467 | 0.85 | TRPV1 (0.57) | TRPV1NPBWR1CHEK2RUNX1CBFB | |
| SCHEMBL11903644 | 0.84 | TRPV1 (0.56) | TRPV1CHEK2RUNX1CBFBKDM4E | |
| SCHEMBL13305849 | 0.83 | TRPV1 (0.55) | TRPV1CHEK2RUNX1CBFBACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293780-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | U.S. DEPARTMENT OF ENERGY (US) | 2012-10-23 | — | — | US | disclosed |
| US-8242284-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 2012-08-14 | — | — | US | disclosed |