SCHEMBL11903473

SCHEMBL11903473

N#Cc1ccc(-c2ccc3c(c2)C2(CCCC2)C(=S)N3)[nH]1

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PGR P06401 20/20 0.72
NR3C1 P04150 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6407840 0.85 PGR (0.98) PGR
SCHEMBL6409727 0.84 PGR (1.00) PGR
SCHEMBL4104125 0.82 PGR (0.71) PGRNR3C1
SCHEMBL4104128 0.82 PGR (0.71) PGRNR3C1
SCHEMBL3422468 0.81 PGR (0.70) PGR
SCHEMBL4534292 0.81 PGR (0.70) PGR
SCHEMBL6379697 0.79 PGR (0.53) PGRNR3C1
SCHEMBL6379691 0.79 PGR (0.63) PGRNR3C1
SCHEMBL4104108 0.78 PGR (1.00) PGRNR3C1
SCHEMBL7684040 0.74 PGR (0.59) PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8242098-B2 Methods of treating hormone-related conditions using thio-oxindole derivatives WYETH LLC (US) 2012-08-14 US claimed