SCHEMBL6379697

SCHEMBL6379697

N#Cc1ccc(Cc2ccc3c(c2)C2(CCCCC2)C(=S)N3)[nH]1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PGR P06401 20/20 0.53
NR3C1 P04150 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11903473 0.79 PGR (0.72) PGRNR3C1
SCHEMBL4104108 0.69 PGR (1.00) PGRNR3C1
SCHEMBL6379691 0.68 PGR (0.63) PGRNR3C1
SCHEMBL71701 0.66 PGR (0.60) PGR
SCHEMBL6409727 0.66 PGR (1.00) PGR
SCHEMBL4093560 0.65 PGR (1.00) PGRNR3C1
SCHEMBL4110098 0.65 PGR (1.00) PGRNR3C1
SCHEMBL4104128 0.64 PGR (0.71) PGRNR3C1
SCHEMBL4104125 0.64 PGR (0.71) PGRNR3C1
SCHEMBL6407840 0.64 PGR (0.98) PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1531806-A4 USE OF THIO-OXINDOLE DERIVATIVES IN TREATMENT OF HORMONE-RELATED CONDITIONS WYETH CORP (US) 2005-09-21 EP claimed
EP-1531806-A2 USE OF THIO-OXINDOLE DERIVATIVES IN TREATMENT OF HORMONE-RELATED CONDITIONS Wyeth (US) 2005-05-25 EP claimed
WO-2004000225-A2 USE OF THIO-OXINDOLE DERIVATIVES IN TREATMENT OF HORMONE-RELATED CONDITIONS WYETH (US) 2003-12-31 WO claimed