SCHEMBL11904077

SCHEMBL11904077

C1=Nc2c(-c3ccc(-c4cccs4)s3)ccnc2[N]1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 4/20 0.38
LTA4H P09960 1/20 0.36
ALDH1A1 P00352 4/20 0.34
GAA P10253 4/20 0.34
KDM4E B2RXH2 3/20 0.34
LMNA P02545 2/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
GLA P06280 2/20 0.34
MAPT P10636 1/20 0.34
HPGD P15428 2/20 0.33
MEN1 O00255 1/20 0.33
NPC1 O15118 1/20 0.33
TP53 P04637 1/20 0.33
POLB P06746 1/20 0.33
NFKB1 P19838 1/20 0.33
MAPK1 P28482 1/20 0.33
CASP1 P29466 1/20 0.33
RAB9A P51151 1/20 0.33
CASP7 P55210 1/20 0.33
NFKB2 Q00653 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2497304 0.90 KDM4E (0.38) ALDH1A1GAAKDM4EL3MBTL1GLA
SCHEMBL11904054 0.75 DPP4 (0.38) DPP4LTA4HALDH1A1GAAKDM4E
SCHEMBL11904112 0.71 ADORA2A (0.43) DPP4LTA4HALDH1A1GAAKDM4E
SCHEMBL11903939 0.71 ALDH1A1 (0.44) DPP4LTA4HALDH1A1GAAKDM4E
SCHEMBL11903852 0.71 ALDH1A1 (0.44) DPP4LTA4HALDH1A1GAAKDM4E
SCHEMBL2498595 0.70 CYP17A1 (0.38) RAB9ATGFBR1CYP17A1
SCHEMBL1023476 0.69 RPS6KB2 (0.37) ALDH1A1GAAKDM4EL3MBTL1GLA
SCHEMBL23611278 0.69 DPP4 (0.65) DPP4LTA4HALDH1A1GAAKDM4E
SCHEMBL2742433 0.69 DPP4 (0.65) DPP4LTA4HALDH1A1GAAKDM4E
SCHEMBL13707354 0.69 DPP4 (0.65) DPP4LTA4HALDH1A1GAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220315926-A1 An Aptamer for Dengue Virus and Related Methods and Products AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2022-10-06 US claimed
EP-3987035-A1 AN APTAMER FOR DENGUE VIRUS AND RELATED METHODS AND PRODUCTS Agency for Science, Technology and Research (SG) 2022-04-27 EP claimed
EP-3918091-A1 METHOD OF SEQUENCING NUCLEIC ACID WITH UNNATURAL BASE PAIRS Agency for Science, Technology and Research (SG) 2021-12-08 EP claimed
WO-2020256639-A1 AN APTAMER FOR DENGUE VIRUS AND RELATED METHODS AND PRODUCTS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2020-12-24 WO claimed
WO-2020159435-A1 METHOD OF SEQUENCING NUCLEIC ACID WITH UNNATURAL BASE PAIRS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2020-08-06 WO claimed
US-9285319-B2 Nucleic acid base analogs with quenching and fluorescent activities and applications thereof RIKEN (JP) 2016-03-15 US claimed
EP-2487180-B1 NOVEL ARTIFICIAL FLUORESCENT BASES RIKEN (JP) 2014-12-03 EP claimed
US-8895712-B2 Artificial base pair capable of forming specific base pair RIKEN (JP) 2014-11-25 US claimed
US-20130122506-A1 NUCLEIC ACID BASE ANALOGS WITH QUENCHING AND FLUORESCENT ACTIVITIES AND APPLICATIONS THEREOF TAGCYX BIOTECHNOLOGIES C/O RIKEN (JP) 2013-05-16 US claimed
EP-2562255-A1 NUCLEIC ACID BASE ANALOG WITH QUENCHING CHARACTERISTICS AND FLUORESCENCE AND APPLICATION THEREOF Riken (JP) 2013-02-27 EP claimed
US-20120245340-A1 NOVEL ARTIFICIAL FLUORESCENT BASES TAGCYX BIOTECHNOLOGIES (JP) 2012-09-27 US claimed
US-20120231462-A1 ARTIFICIAL BASE PAIR CAPABLE OF FORMING SPECIFIC BASE PAIR TAGCYX BIOTECHNOLOGIES (JP) 2012-09-13 US claimed
EP-2487180-A1 NOVEL ARTIFICIAL FLUORESCENT BASES Riken (JP) 2012-08-15 EP claimed
EP-2487181-A1 ARTIFICIAL BASE PAIR CAPABLE OF FORMING SPECIFIC BASE PAIR Riken (JP) 2012-08-15 EP claimed
US-20220315926-A1 An Aptamer for Dengue Virus and Related Methods and Products AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2022-10-06 US disclosed
EP-3987035-A1 AN APTAMER FOR DENGUE VIRUS AND RELATED METHODS AND PRODUCTS Agency for Science, Technology and Research (SG) 2022-04-27 EP disclosed
EP-3918091-A1 METHOD OF SEQUENCING NUCLEIC ACID WITH UNNATURAL BASE PAIRS Agency for Science, Technology and Research (SG) 2021-12-08 EP disclosed
US-20120231462-A1 ARTIFICIAL BASE PAIR CAPABLE OF FORMING SPECIFIC BASE PAIR TAGCYX BIOTECHNOLOGIES (JP) 2012-09-13 US disclosed
EP-2487181-A1 ARTIFICIAL BASE PAIR CAPABLE OF FORMING SPECIFIC BASE PAIR Riken (JP) 2012-08-15 EP disclosed
EP-2487180-A1 NOVEL ARTIFICIAL FLUORESCENT BASES Riken (JP) 2012-08-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120231462-A1 ARTIFICIAL BASE PAIR CAPABLE OF FORMING SPECIFIC BASE PAIR NSUN2, EIF2AK2, NSUN3 DPP4 2281/4885LTA4H 4641/4885ALDH1A1 1963/4885
US-20120245340-A1 NOVEL ARTIFICIAL FLUORESCENT BASES NUDT1, NT5C3B, NSUN2 DPP4 826/4885LTA4H 3064/4885ALDH1A1 566/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.