Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB2 | Q9UBS0 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ADK | P55263 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023046 | 0.76 | ADORA2A (0.51) | RPS6KB2MEN1KMT2AKDM4EHPGD | |
| SCHEMBL2497304 | 0.74 | KDM4E (0.38) | MEN1KMT2AKDM4EHPGDALDH1A1 | |
| SCHEMBL11904077 | 0.69 | DPP4 (0.38) | MEN1KMT2AKDM4EHPGDALDH1A1 | |
| SCHEMBL11904112 | 0.68 | ADORA2A (0.43) | MEN1KMT2AKDM4EHPGDALDH1A1 | |
| SCHEMBL1033845 | 0.66 | NPC1 (0.43) | RPS6KB2MEN1KMT2AKDM4EHPGD | |
| SCHEMBL14843470 | 0.65 | ADORA2A (0.57) | RPS6KB2MEN1KMT2AKDM4EHPGD | |
| SCHEMBL1029868 | 0.61 | SMN1; SMN2 (0.51) | KDM4EALDH1A1NPC1RAB9ATDO2 | |
| SCHEMBL1029867 | 0.61 | CDK5 (0.44) | RPS6KB2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL31690465 | 0.61 | JAK2 (0.57) | CDK5PDE3BPDE3A | |
| SCHEMBL1781579 | 0.61 | KDM4E (0.56) | RPS6KB2MEN1KMT2AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8212014-B2 | Artificial base pairs and uses thereof | RIKEN (JP) | 2012-07-03 | — | — | US | claimed |
| EP-1921141-B1 | NOVEL ARTIFICIAL BASE PAIR AND USE THEREOF | RIKEN (JP) | 2011-01-12 | — | — | EP | claimed |
| US-20100323364-A1 | MODIFIED tRNA CONTAINING UNNATURAL BASE AND USE THEREOF | THE UNIVERSITY OF TOKYO (JP) | 2010-12-23 | — | — | US | claimed |
| US-20100285598-A1 | Novel Artificial Base Pairs and Uses Thereof | RIKEN (JP) | 2010-11-11 | — | — | US | claimed |
| EP-2246428-A1 | MODIFIED TRNA CONTAINING NON-NATURAL NUCLEOTIDE AND USE THEREOF | The University of Tokyo (JP) | 2010-11-03 | — | — | EP | claimed |
| EP-1921141-A1 | NOVEL ARTIFICIAL BASE PAIR AND USE THEREOF | Riken (JP) | 2008-05-14 | — | — | EP | claimed |
| US-8715984-B2 | Modified tRNA containing unnatural base and use thereof | RIKEN (JP) | 2014-05-06 | — | — | US | disclosed |
| US-8212014-B2 | Artificial base pairs and uses thereof | RIKEN (JP) | 2012-07-03 | — | — | US | disclosed |
| EP-1921141-B1 | NOVEL ARTIFICIAL BASE PAIR AND USE THEREOF | RIKEN (JP) | 2011-01-12 | — | — | EP | disclosed |
| US-20100323364-A1 | MODIFIED tRNA CONTAINING UNNATURAL BASE AND USE THEREOF | THE UNIVERSITY OF TOKYO (JP) | 2010-12-23 | — | — | US | disclosed |
| US-20100285598-A1 | Novel Artificial Base Pairs and Uses Thereof | RIKEN (JP) | 2010-11-11 | — | — | US | disclosed |
| EP-2246428-A1 | MODIFIED TRNA CONTAINING NON-NATURAL NUCLEOTIDE AND USE THEREOF | The University of Tokyo (JP) | 2010-11-03 | — | — | EP | disclosed |
| EP-1921141-A1 | NOVEL ARTIFICIAL BASE PAIR AND USE THEREOF | Riken (JP) | 2008-05-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100285598-A1 | Novel Artificial Base Pairs and Uses Thereof | POLRMT, RNGTT, POLN | RPS6KB2 1103/4885MEN1 2596/4885KMT2A 1692/4885 |
| US-20100323364-A1 | MODIFIED tRNA CONTAINING UNNATURAL BASE AND USE THEREOF | TRMT1, NSUN3, TARBP1 | RPS6KB2 1012/4885MEN1 3591/4885KMT2A 1025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.