Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.43 |
| ▸ | LNPEP | Q9UIQ6 | 5/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15127991 | 0.76 | GPR88 (0.48) | GPR88CARM1SMN1; SMN2L3MBTL1 | |
| SCHEMBL11904814 | 0.73 | GPR88 (0.55) | GPR88CARM1FKBP1ASMN1; SMN2L3MBTL1 | |
| SCHEMBL1554711 | 0.73 | GPR88 (0.55) | GPR88CARM1FKBP1ASMN1; SMN2L3MBTL1 | |
| SCHEMBL1554714 | 0.73 | GPR88 (0.55) | GPR88CARM1FKBP1ASMN1; SMN2L3MBTL1 | |
| SCHEMBL15134951 | 0.71 | GPR88 (0.45) | GPR88CARM1FKBP1ASMN1; SMN2L3MBTL1 | |
| SCHEMBL19347299 | 0.71 | SKP2 (0.41) | ATM | |
| SCHEMBL12431876 | 0.70 | GPR88 (0.45) | GPR88LNPEPPPARGPPARANPSR1 | |
| SCHEMBL31664434 | 0.70 | SMN1; SMN2 (0.40) | GPR88CARM1FKBP1ASMN1; SMN2TDP1 | |
| SCHEMBL27823826 | 0.69 | GPR88 (0.44) | GPR88LNPEPPPARGPPARASMN1; SMN2 | |
| SCHEMBL31664414 | 0.69 | SMN1; SMN2 (0.45) | GPR88CARM1FKBP1ASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486030-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |