Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | HTR6 | P50406 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | YWHAG | P61981 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23708642 | 0.88 | KDM4E (0.60) | ALDH1A1TSHRHSD17B10NPC1SMN1; SMN2 | |
| SCHEMBL11217216 | 0.86 | HSD17B10 (0.53) | ALDH1A1TSHRHSD17B10USP2HTR6 | |
| SCHEMBL11908425 | 0.84 | NPC1 (0.71) | ALDH1A1TSHRHSD17B10USP2HTR6 | |
| SCHEMBL11907676 | 0.83 | SMN1; SMN2 (0.50) | ALDH1A1TSHRHSD17B10NPC1SMN1; SMN2 | |
| SCHEMBL3407551 | 0.79 | HTR6 (0.66) | ALDH1A1TSHRHSD17B10USP2HTR6 | |
| SCHEMBL1450313 | 0.78 | NPC1 (0.70) | ALDH1A1TSHRHSD17B10HTR6NPC1 | |
| SCHEMBL6630880 | 0.78 | LTA4H (0.54) | HSD17B10HTR6NPC1ALOX15MAPT | |
| SCHEMBL2869405 | 0.77 | HTR6 (0.61) | ALDH1A1TSHRHSD17B10USP2HTR6 | |
| Hydrochloric Acid SCHEMBL27658727 | 0.77 | NPC1 (0.68) | ALDH1A1TSHRHSD17B10HTR6NPC1 | |
| SCHEMBL11907000 | 0.77 | GAA (0.50) | ALDH1A1TSHRHSD17B10NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140249135-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2014-09-04 | — | — | US | disclosed |
| US-8822497-B2 | PIM kinase inhibitors and methods of their use | NOVARTIS AG (CH) | 2014-09-02 | — | — | US | disclosed |
| US-20120208815-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140249135-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | PIM1, PIM2, PIM3 | ALDH1A1 2176/4885TSHR 2328/4885HSD17B10 4209/4885 |
| US-20120208815-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | PIM1, PIM2, PIM3 | ALDH1A1 2176/4885TSHR 2328/4885HSD17B10 4209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.