Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LNPEP | Q9UIQ6 | 5/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29848332 | 0.87 | IDO1 (0.51) | PTGER4KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL23286972 | 0.84 | PTGER4 (0.63) | PTGER4KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL11909200 | 0.83 | MAPT (0.48) | KDM4EKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL11909199 | 0.83 | MAPT (0.48) | KDM4EKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL27478656 | 0.81 | PTGER4 (0.57) | PTGER4KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL28754390 | 0.80 | ALDH1A1 (0.45) | PTGER4KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL28754451 | 0.80 | ALDH1A1 (0.45) | PTGER4KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL28754391 | 0.80 | ALDH1A1 (0.45) | PTGER4KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL11909187 | 0.79 | GRIN2B (0.43) | KMT2AMEN1HDAC1 | |
| SCHEMBL21681876 | 0.79 | DRD2 (0.40) | PTGER4KDM4EKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120208827-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208827-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | FASN, FADS1, FADS2 | PTGER4 2567/4885KDM4E 1624/4885KMT2A 2560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.