SCHEMBL1190916

SCHEMBL1190916

C1CCN2CCNC[C@H]2C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 1/20 1.00
KMT2A Q03164 2/20 0.34
HPGD P15428 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
L3MBTL3 Q96JM7 3/20 0.33
L3MBTL1 Q9Y468 3/20 0.33
HTR2C P28335 2/20 0.33
HTR2B P41595 2/20 0.33
HTR2A P28223 1/20 0.32
HRH3 Q9Y5N1 1/20 0.32
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP2D6 P10635 3/20 0.31
MEN1 O00255 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL65291 1.00 HTR6 (1.00) HTR6KMT2AHPGDSMN1; SMN2L3MBTL3
SCHEMBL3522066 1.00 HTR6 (1.00) HTR6KMT2AHPGDSMN1; SMN2L3MBTL3
SCHEMBL8499402 0.98 HTR6 (0.96) HTR6KMT2AHPGDSMN1; SMN2L3MBTL3
SCHEMBL398118 0.98 HTR6 (0.96) HTR6KMT2AHPGDSMN1; SMN2L3MBTL3
Hydrochloric Acid SCHEMBL63700 0.98 HTR6 (0.96) HTR6KMT2AHPGDSMN1; SMN2L3MBTL3
SCHEMBL8502194 0.98 HTR6 (0.96) HTR6KMT2AHPGDSMN1; SMN2L3MBTL3
SCHEMBL8501091 0.98 HTR6 (0.96) HTR6KMT2AHPGDSMN1; SMN2L3MBTL3
SCHEMBL8503565 0.98 HTR6 (0.96) HTR6KMT2AHPGDSMN1; SMN2L3MBTL3
Hydrochloric Acid SCHEMBL20522843 0.98 HTR6 (0.96) HTR6KMT2AHPGDSMN1; SMN2L3MBTL3
SCHEMBL6314141 0.96 HTR6 (0.92) HTR6KMT2AHPGDSMN1; SMN2L3MBTL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 142 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12624053-B2 Ras inhibitors Revolution Medicines, Inc. (US) 2026-05-12 US disclosed
US-20260070930-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT 2026-03-12 US disclosed
EP-3623372-B1 PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS VALO HEALTH INC (US) 2026-02-04 EP disclosed
US-20250388608-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2025-12-25 US disclosed
EP-4665454-A1 IMIDAZOTRIAZINE IL-17A MODULATORS AND USES THEREOF Dice Alpha, Inc. (US) 2025-12-24 EP disclosed
US-20250376482-A1 TRICYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER HOFFMANN-LA ROCHE INC. (US) 2025-12-11 US disclosed
US-20250282762-A1 PYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF NOVARTIS AG (CH) 2025-09-11 US disclosed
US-20250197423-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2025-06-19 US disclosed
US-20250145643-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2025-05-08 US disclosed
CN-119798279-A RAS inhibitors 锐新医药公司 2025-04-11 CN disclosed
US-6906060-B2 Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines NOVO NORDISK A/S (DK) 2005-06-14 US disclosed
EP-1513842-A1 SUBSTITUTED HEXAHYDROPYRROLO (1,2-A)PYRAZINES, OCTAHYDROPYRIDO(1,2-A)PYRAZINES AND DECAHYDROPYRAZINO(1,2-A)AZEPINES NOVO NORDISK A/S (DK) 2005-03-16 EP disclosed
US-20040023946-A1 Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines VTVX HOLDINGS II LLC 2004-02-05 US disclosed
WO-2004000832-A1 1-[(INDOL-3-YL)CARBONYL] PIPERAZINE DERIVATIVES AKZO NOBEL N.V. (NL) 2003-12-31 WO disclosed
US-20030236259-A1 Novel aryl- and heteroarylpiperazines HIGH POINT PHARMACEUTICALS, LLC 2003-12-25 US disclosed
WO-2003104235-A1 SUBSTITUTED HEXAHYDROPYRROLO[1,2-A]PYRAZINES, OCTAHYDROPYRIDO[1,2-A]PYRAZINES AND DECAHYDROPYRAZINO[1,2-A]AZEPINES NOVO NORDISK A/S (DK) 2003-12-18 WO disclosed
EP-0797577-B1 BICYCLIC NONANE AND DECANE COMPOUNDS HAVING DOPAMINE RECEPTOR AFFINITY ALLELIX BIOPHARMA (CA) 2000-07-26 EP disclosed
EP-0797577-A1 BICYCLIC NONANE AND DECANE COMPOUNDS HAVING DOPAMINE RECEPTOR AFFINITY Allelix Biopharmaceuticals Inc. (CA) 1997-10-01 EP disclosed
US-5576314-A Bicyclic nonane and decane compounds having dopamine receptor affinity ALLELIX BIOPHARMACEUTICALS INC. (CA) 1996-11-19 US disclosed
WO-1996018630-A1 BICYCLIC NONANE AND DECANE COMPOUNDS HAVING DOPAMINE RECEPTOR AFFINITY ALLELIX BIOPHARMACEUTICALS INC. (CA) 1996-06-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260070930-A1 RAS INHIBITORS KRAS, NRAS, RIN1 HTR6 4346/4885KMT2A 4067/4885HPGD 1566/4885
US-20040023946-A1 Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines HRH2, HRH4, HRH1 HTR6 119/4885KMT2A 632/4885HPGD 754/4885
US-20250145643-A1 RAS INHIBITORS KRAS, NRAS, HRAS HTR6 4617/4885KMT2A 3685/4885HPGD 3002/4885
US-20250376482-A1 TRICYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CCNI, TOP2B HTR6 2631/4885KMT2A 1020/4885HPGD 2495/4885
US-20250282762-A1 PYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF HBZ, ZFX, WIZ HTR6 3197/4885KMT2A 1734/4885HPGD 1030/4885
US-20030236259-A1 Novel aryl- and heteroarylpiperazines HRH3, HRH2, HRH4 HTR6 35/4885KMT2A 301/4885HPGD 870/4885
US-12624053-B2 Ras inhibitors KRAS, NRAS, HMGCR HTR6 4048/4885KMT2A 3666/4885HPGD 1695/4885
US-20250197423-A1 RAS INHIBITORS KRAS, NRAS, HRAS HTR6 4617/4885KMT2A 3685/4885HPGD 3002/4885
US-20250388608-A1 RAS INHIBITORS KRAS, NRAS, HMGCR HTR6 4048/4885KMT2A 3666/4885HPGD 1695/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.