Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.36 |
| ▸ | TRAP1 | Q12931 | 4/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | BCL6 | P41182 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23885052 | 0.78 | KMO (0.42) | KMOKDM4ETP53HPGDHSD17B10 | |
| SCHEMBL7919917 | 0.78 | CYP1A2 (0.39) | HSP90AA1TRAP1HSP90AB1HSP90B1SMN1; SMN2 | |
| SCHEMBL2189832 | 0.77 | ADORA3 (0.43) | KDM4ETP53HPGDHSD17B10HSP90AA1 | |
| SCHEMBL23055223 | 0.76 | KMO (0.50) | KMOKDM4ETP53HPGDHSD17B10 | |
| SCHEMBL17926576 | 0.76 | HSP90AA1 (0.39) | KDM4EHPGDHSD17B10HSP90AA1TRAP1 | |
| SCHEMBL2786472 | 0.75 | ALDH1A1 (0.54) | KDM4EHPGDHSD17B10HSP90AA1TRAP1 | |
| SCHEMBL31194508 | 0.75 | ALDH1A1 (0.54) | KDM4EHPGDHSD17B10HSP90AA1TRAP1 | |
| SCHEMBL12787612 | 0.75 | KMO (0.38) | KMOKDM4ETP53HPGDHSD17B10 | |
| SCHEMBL2786539 | 0.74 | PDE1A (0.42) | HSP90AA1TRAP1HSP90AB1HSP90B1NPC1 | |
| SCHEMBL7904205 | 0.74 | PLK4 (0.41) | KDM4EHPGDHSD17B10HSP90AA1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8741896-B2 | Pyrazolopyrimidine derivatives | MERCK PATENT GMBH (DE) | 2014-06-03 | — | — | US | disclosed |
| US-20120208808-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208808-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES | PDPK1, PIK3R5, NLRP1 | KMO 2456/4885KDM4E 3029/4885TP53 602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.