Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23715099 | 0.89 | ADRA2A (0.46) | ADRA2AGAAALDH1A1MAPTHSD17B10 | |
| SCHEMBL13616553 | 0.85 | ADRA2A (0.41) | ADRA2AGAAALDH1A1MAPTHSD17B10 | |
| SCHEMBL21933121 | 0.85 | ADRA2A (0.41) | ADRA2AGAAALDH1A1MAPTHSD17B10 | |
| SCHEMBL13630579 | 0.85 | ADRA2A (0.41) | ADRA2AGAAALDH1A1MAPTHSD17B10 | |
| SCHEMBL7920992 | 0.81 | HCRTR2 (0.45) | ADRA2AGAAALDH1A1MAPTHSD17B10 | |
| SCHEMBL24075122 | 0.80 | MAP3K14 (0.51) | ADRA2AHTR2CHTR1ASLC6A2HTR2B | |
| SCHEMBL25202695 | 0.80 | ADRA2A (0.50) | ADRA2AMAPTHTR2CHTR2BHCRTR2 | |
| SCHEMBL11926954 | 0.80 | ADRA2A (0.50) | ADRA2AGAAALDH1A1MAPTHSD17B10 | |
| SCHEMBL24675181 | 0.80 | DRD3 (0.43) | GAAALDH1A1MAPTHSD17B10MAP3K14 | |
| SCHEMBL24675182 | 0.80 | DRD3 (0.43) | GAAALDH1A1MAPTHSD17B10MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |
| US-20230141809-A1 | QUINOLINE DERIVATIVES | ELANCO ANIMAL HEALTH GMBH (DE) | 2023-05-11 | — | — | US | disclosed |
| US-20150126493-A1 | BICYCLIC SULFONE COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | MERCK SHARP & DOHME LLC | 2015-05-07 | — | — | US | disclosed |
| US-8921360-B2 | Heterobicycle-substituted azolyl benzene fungicides | E. I. DU PONT DE NEMOURS AND COMPANY | 2014-12-30 | — | — | US | disclosed |
| US-8921360-B2 | Heterobicycle-substituted azolyl benzene fungicides | E. I. DU PONT DE NEMOURS AND COMPANY | 2014-12-30 | — | — | US | disclosed |
| EP-2757096-A9 | Inhibitors of human immunodeficiency virus replication | GILEAD SCIENCES, INC. (US) | 2014-11-26 | — | — | EP | disclosed |
| EP-2757096-A1 | Inhibitors of human immunodeficiency virus replication | GILEAD SCIENCES, INC. (US) | 2014-07-23 | — | — | EP | disclosed |
| EP-2220046-B1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | GILEAD SCIENCES INC (US) | 2014-06-18 | — | — | EP | disclosed |
| EP-2220084-B1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | GILEAD SCIENCES INC (US) | 2014-02-19 | — | — | EP | disclosed |
| EP-2493880-B1 | HETEROBICYCLE-SUBSTITUTED AZOLYL BENZENE FUNGICIDES | DU PONT (US) | 2013-09-18 | — | — | EP | disclosed |
| US-8461180-B2 | Inhibitors of human immunodeficiency virus replication | GILEAD SCIENCES, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| EP-2574610-A1 | Inhibitors of human immonodeficiency virus replication | GILEAD SCIENCES, INC. (US) | 2013-04-03 | — | — | EP | disclosed |
| US-20120202815-A1 | HETEROBICYCLE-SUBSTITUTED AZOLYL BENZENE FUNGICIDES | E.I.DU PONT DE NEMOURS AND COMPANY (US) | 2012-08-09 | — | — | US | disclosed |
| US-20120202815-A1 | HETEROBICYCLE-SUBSTITUTED AZOLYL BENZENE FUNGICIDES | E.I.DU PONT DE NEMOURS AND COMPANY (US) | 2012-08-09 | — | — | US | disclosed |
| WO-2011059619-A1 | HETEROBICYCLE-SUBSTITUTED AZOLYL BENZENE FUNGICIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202815-A1 | HETEROBICYCLE-SUBSTITUTED AZOLYL BENZENE FUNGICIDES | CBR3, CBR1, CYP2S1 | ADRA2A 3603/4885GAA 4112/4885ALDH1A1 3110/4885 |
| US-20150126493-A1 | BICYCLIC SULFONE COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | RORC, RORB, RORA | ADRA2A 1451/4885GAA 1426/4885ALDH1A1 374/4885 |
| US-20230141809-A1 | QUINOLINE DERIVATIVES | RECQL, NQO2, QTRT2 | ADRA2A 628/4885GAA 804/4885ALDH1A1 1234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.