Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.73 |
| ▸ | DRD4 | P21917 | 6/20 | 0.73 |
| ▸ | DRD2 | P14416 | 6/20 | 0.73 |
| ▸ | DRD3 | P35462 | 6/20 | 0.73 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.73 |
| ▸ | HRH1 | P35367 | 4/20 | 0.73 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.73 |
| ▸ | HTR2A | P28223 | 4/20 | 0.73 |
| ▸ | HRH2 | P25021 | 3/20 | 0.73 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.73 |
| ▸ | HTR1A | P08908 | 3/20 | 0.73 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.73 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.73 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.73 |
| ▸ | DRD1 | P21728 | 3/20 | 0.73 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.73 |
| ▸ | HTR2C | P28335 | 3/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.73 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31098221 | 0.85 | HRH4 (0.69) | HRH4DRD4DRD2DRD3CHRM1 | |
| Loxapine SCHEMBL19386241 | 0.84 | HRH4 (1.00) | HRH4DRD4DRD2DRD3CHRM1 | |
| Loxapine SCHEMBL29374082 | 0.84 | HRH4 (1.00) | HRH4DRD4DRD2DRD3CHRM1 | |
| Loxapine SCHEMBL94146 | 0.84 | HRH4 (1.00) | HRH4DRD4DRD2DRD3CHRM1 | |
| Loxapine SCHEMBL29482385 | 0.84 | HRH4 (1.00) | HRH4DRD4DRD2DRD3CHRM1 | |
| Loxapine SCHEMBL30324780 | 0.84 | HRH4 (1.00) | HRH4DRD4DRD2DRD3CHRM1 | |
| SCHEMBL25410757 | 0.84 | HRH4 (0.77) | HRH4DRD4DRD2DRD3CHRM1 | |
| Loxapine SCHEMBL30903930 | 0.83 | HRH4 (0.98) | HRH4DRD4DRD2DRD3CHRM1 | |
| Loxapine SCHEMBL4164270 | 0.83 | HRH4 (0.98) | HRH4DRD4DRD2DRD3CHRM1 | |
| Loxapine SCHEMBL41625 | 0.83 | HRH4 (0.98) | HRH4DRD4DRD2DRD3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230165812-A1 | NOCICEPTOR NEURONS CONTROL CANCER IMMUNOSURVEILLANCE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-06-01 | — | — | US | disclosed |
| US-20230165812-A1 | NOCICEPTOR NEURONS CONTROL CANCER IMMUNOSURVEILLANCE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-06-01 | — | — | US | disclosed |
| US-20220016046-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2022-01-20 | — | — | US | disclosed |
| US-20210290561-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2021-09-23 | — | — | US | disclosed |
| US-20210186906-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-06-24 | — | — | US | disclosed |
| US-11021443-B2 | Charged ion channel blockers and methods for use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-06-01 | — | — | US | disclosed |
| US-20210030695-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2021-02-04 | — | — | US | disclosed |
| US-20200377459-A1 | CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-12-03 | — | — | US | disclosed |
| US-10729664-B2 | Permanently charged sodium and calcium channel blockers as anti-inflammatory agents | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-08-04 | — | — | US | disclosed |
| US-20190216747-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS | CHILDREN'S MEDICAL CENTER CORPORATION | 2019-07-18 | — | — | US | disclosed |
| EP-2995303-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS | President and Fellows of Harvard College (US) | 2016-03-16 | — | — | EP | disclosed |
| US-20150087714-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2015-03-26 | — | — | US | disclosed |
| US-20150087714-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2015-03-26 | — | — | US | disclosed |
| US-20120172429-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI- INFLAMMATORY AGENTS | THE GENERAL HOSPITAL CORPORATION | 2012-07-05 | — | — | US | disclosed |
| US-20120172429-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI- INFLAMMATORY AGENTS | THE GENERAL HOSPITAL CORPORATION | 2012-07-05 | — | — | US | disclosed |
| US-20110086818-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086818-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2011-04-14 | — | — | US | disclosed |
| US-20100099772-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-22 | — | — | US | disclosed |
| US-20100099772-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-22 | — | — | US | disclosed |
| WO-2009114139-A2 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200377459-A1 | CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE | TRPV1, TRPV2, TRPA1 | HRH4 149/4885DRD4 3284/4885DRD2 2743/4885 |
| US-20120172429-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI- INFLAMMATORY AGENTS | TRPV1, CACNA1B, ORAI1 | HRH4 370/4885DRD4 2680/4885DRD2 2545/4885 |
| US-10729664-B2 | Permanently charged sodium and calcium channel blockers as anti-inflammatory agents | TRPV1, CACNA1B, ORAI1 | HRH4 370/4885DRD4 2680/4885DRD2 2545/4885 |
| US-20210030695-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS | TRPV1, CACNA1B, ORAI1 | HRH4 370/4885DRD4 2680/4885DRD2 2545/4885 |
| US-20230165812-A1 | NOCICEPTOR NEURONS CONTROL CANCER IMMUNOSURVEILLANCE | OPRL1, MRGPRX1, RAMP1 | HRH4 1435/4885DRD4 2125/4885DRD2 1725/4885 |
| US-11021443-B2 | Charged ion channel blockers and methods for use | TRPV1, TRPV2, TRPA1 | HRH4 149/4885DRD4 3284/4885DRD2 2743/4885 |
| US-20110086818-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS | TRPV1, OPRL1, ITCH | HRH4 156/4885DRD4 2750/4885DRD2 2286/4885 |
| US-20100099772-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | TRPV1, TRPV2, TRPV3 | HRH4 87/4885DRD4 2924/4885DRD2 2087/4885 |
| US-20150087714-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | TRPV1, TRPV2, TRPA1 | HRH4 107/4885DRD4 3076/4885DRD2 2070/4885 |
| US-20190216747-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS | TRPV1, CACNA1B, ORAI1 | HRH4 370/4885DRD4 2680/4885DRD2 2545/4885 |
| US-20210290561-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS | TRPV1, CACNA1B, ORAI1 | HRH4 370/4885DRD4 2680/4885DRD2 2545/4885 |
| US-20220016046-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS | CACNA1B, TRPV1, ORAI1 | HRH4 411/4885DRD4 2650/4885DRD2 2442/4885 |
| US-20210186906-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | TRPV1, TRPV2, TRPV3 | HRH4 87/4885DRD4 2924/4885DRD2 2087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.