Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 3/20 | 0.59 |
| ▸ | MAOA | P21397 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | DPP4 | P27487 | 2/20 | 0.58 |
| ▸ | CTSL | P07711 | 2/20 | 0.56 |
| ▸ | CTSB | P07858 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.52 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11937142 | 0.86 | CHRNA7 (0.63) | MAPTMEN1HSP90AA1KMT2ACHRNA7 | |
| SCHEMBL3064890 | 0.85 | MAPT (0.68) | MAPTMEN1HSP90AA1KMT2AMAOB | |
| SCHEMBL3064887 | 0.85 | MAPT (0.68) | MAPTMEN1HSP90AA1KMT2AMAOB | |
| SCHEMBL29406300 | 0.85 | MAPT (0.68) | MAPTMEN1HSP90AA1KMT2AMAOB | |
| SCHEMBL979673 | 0.84 | MAOB (0.63) | MAPTMEN1KMT2AMAOBMAOA | |
| SCHEMBL979672 | 0.84 | MAOB (0.63) | MAPTMEN1KMT2AMAOBMAOA | |
| SCHEMBL11703114 | 0.79 | ALDH1A1 (0.58) | MAPTMEN1KMT2ARAB9APOLB | |
| SCHEMBL28068228 | 0.79 | TYR (0.72) | MAPTMEN1HSP90AA1KMT2AMAOB | |
| SCHEMBL17370987 | 0.78 | CHRNA7 (0.71) | MAPTMEN1HSP90AA1KMT2AMAOB | |
| SCHEMBL28706431 | 0.78 | MAPT (1.00) | MAPTMEN1HSP90AA1KMT2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120277252-A1 | Antibacterial Agents and Methods of Use Thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2012-11-01 | — | — | US | disclosed |
| US-8227616-B2 | Cyanopyridine antibacterial agents and methods of use thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-07-24 | — | — | US | disclosed |
| US-20100261763-A1 | ANTIBACTERIAL AGENTS AND METHODS OF USE THEREOF | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-10-14 | — | — | US | disclosed |
| US-7737164-B2 | Cyanopyridine antibacterial agents | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-06-15 | — | — | US | disclosed |
| US-20080009528-A1 | ANTIBACTERIAL AGENTS AND RELATED SCREENING METHODS USING SMALL MOLECULE MACROARRAYS | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277252-A1 | Antibacterial Agents and Methods of Use Thereof | FDPS, ABCG2, DUT | MAPT 4708/4885MEN1 3582/4885HSP90AA1 1184/4885 |
| US-20080009528-A1 | ANTIBACTERIAL AGENTS AND RELATED SCREENING METHODS USING SMALL MOLECULE MACROARRAYS | PCNA, ABCG2, API5 | MAPT 4803/4885MEN1 3709/4885HSP90AA1 720/4885 |
| US-20100261763-A1 | ANTIBACTERIAL AGENTS AND METHODS OF USE THEREOF | FDPS, CYP3A5, ABCG2 | MAPT 4715/4885MEN1 3578/4885HSP90AA1 1401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.