SCHEMBL11938496

SCHEMBL11938496

CCCc1nn(C)c(C(=O)NCc2ccc(C(C)(C)C)cc2)c1Cl

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 6/20 0.72
▸ MAPT P10636 3/20 0.72
▸ ATM Q13315 2/20 0.72
▸ L3MBTL1 Q9Y468 2/20 0.72
▸ RAB9A P51151 7/20 0.56
▸ NPC1 O15118 5/20 0.56
▸ SMN1; SMN2 Q16637 4/20 0.55
▸ KMT2A Q03164 2/20 0.55
▸ GALR3 O60755 1/20 0.55
▸ NR2F2 P24468 1/20 0.55
▸ NR1I2 O75469 1/20 0.53
▸ AHR P35869 1/20 0.53
▸ POLB P06746 1/20 0.53
▸ ALDH1A1 P00352 1/20 0.52
▸ MEN1 O00255 1/20 0.51
▸ CYP1A2 P05177 1/20 0.51
▸ CYP2C19 P33261 1/20 0.51
▸ KDM4E B2RXH2 1/20 0.50
▸ HTT P42858 1/20 0.50
▸ EPHX2 P34913 7/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tebufenpyrad SCHEMBL26848 0.91 LMNA (0.59) LMNAMAPTATML3MBTL1RAB9A
Tebufenpyrad SCHEMBL8407688 0.91 LMNA (0.59) LMNAMAPTATML3MBTL1RAB9A
SCHEMBL11938500 0.90 LMNA (0.59) LMNAMAPTATML3MBTL1RAB9A
SCHEMBL13557817 0.90 LMNA (0.59) LMNAMAPTATML3MBTL1RAB9A
SCHEMBL20968014 0.90 LMNA (0.59) LMNAMAPTATML3MBTL1RAB9A
SCHEMBL9527642 0.84 LMNA (0.77) LMNAMAPTATML3MBTL1RAB9A
SCHEMBL11938556 0.83 LMNA (0.58) LMNAMAPTATML3MBTL1RAB9A
SCHEMBL20968008 0.82 LMNA (0.57) LMNAMAPTATML3MBTL1RAB9A
SCHEMBL11938558 0.82 LMNA (0.57) LMNAMAPTATML3MBTL1RAB9A
SCHEMBL19185689 0.81 LMNA (0.56) LMNAMAPTATML3MBTL1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8226929-B2 Administering to a patient a contrast agent (pyridimifen, fenazaquin) which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging LANTHEUS MEDICAL IMAGING, INC. (US) 2012-07-24 — — US disclosed
US-20080112884-A1 CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING BRISTOL-MYERS SQUIBB PHARMA COMPANY 2008-05-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080112884-A1 CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING TNNI3, TNNT2, FABP3 LMNA 3348/4885MAPT 4043/4885ATM 3259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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