Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.80 |
| ▸ | CASP3 | P42574 | 1/20 | 0.80 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.80 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.80 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.80 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.75 |
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.56 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13379242 | 0.89 | RAB9A (1.00) | RAB9ASMN1; SMN2CASP3SENP8SENP7 | |
| SCHEMBL6686670 | 0.82 | TYR (0.66) | RAB9ASMN1; SMN2CASP3SENP8SENP7 | |
| SCHEMBL8051617 | 0.81 | RAB9A (0.76) | RAB9ASMN1; SMN2CASP3SENP8SENP7 | |
| SCHEMBL1093303 | 0.81 | SMN1; SMN2 (0.60) | RAB9ASMN1; SMN2CASP3SENP8SENP7 | |
| SCHEMBL11765529 | 0.81 | RAB9A (0.58) | RAB9ASMN1; SMN2CASP3SENP8SENP7 | |
| SCHEMBL8346886 | 0.79 | ALDH1A1 (0.67) | RAB9ASMN1; SMN2CASP3SENP8SENP7 | |
| SCHEMBL9830640 | 0.78 | HTR2B (0.60) | RAB9ASMN1; SMN2CASP3SENP8SENP7 | |
| SCHEMBL2048608 | 0.78 | HTR2B (0.57) | RAB9ASMN1; SMN2CASP3SENP8SENP7 | |
| SCHEMBL14098391 | 0.78 | SMN1; SMN2 (0.61) | RAB9ASMN1; SMN2CASP3SENP8SENP7 | |
| SCHEMBL5778957 | 0.78 | SMN1; SMN2 (0.56) | RAB9ASMN1; SMN2CASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046147-A1 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-RELATED DISEASES | UNIVERSITAT DES SAARLANDES (DE) | 2011-02-24 | — | — | US | disclosed |
| EP-2190421-A2 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES | Universität des Saarlandes (DE) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009027346-A2 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES | Universität des Saarlandes (DE) | 2009-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046147-A1 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-RELATED DISEASES | HSD17B1, HSD17B11, HSD17B2 | RAB9A 3724/4885SMN1; SMN2 1914/4885CASP3 4423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.