Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 12/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 1/20 | 0.49 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25491959 | 0.92 | MMP9 (0.51) | CASP1GAARAB9AKMT2ATACR1 | |
| SCHEMBL11940461 | 0.90 | POLB (0.51) | CASP1GAARAB9AKMT2ATACR1 | |
| SCHEMBL25492010 | 0.90 | ABCB1 (0.47) | CASP1GAARAB9AKMT2ATACR1 | |
| SCHEMBL7347418 | 0.88 | CASP1 (0.60) | CASP1ACEMBTPS1ALDH1A1 | |
| SCHEMBL13050803 | 0.88 | GAA (0.50) | CASP1GAARAB9AKMT2ATACR1 | |
| SCHEMBL13296315 | 0.88 | TACR1 (0.64) | KMT2ATACR1ACEMBTPS1POLB | |
| SCHEMBL14234300 | 0.87 | TSHR (0.51) | CASP1RAB9ATACR1MBTPS1POLB | |
| SCHEMBL17042612 | 0.87 | CASP1 (0.50) | CASP1GAATACR1ACEMBTPS1 | |
| SCHEMBL28269655 | 0.87 | EPHX2 (0.52) | CASP1KMT2AACEALDH1A1 | |
| SCHEMBL30621976 | 0.87 | TACR1 (0.61) | CASP1KMT2ATACR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9243028-B2 | Facile amide formation via S-nitroso thioacid intermediates | WASHINGTON STATE UNIVERSITY (US) | 2016-01-26 | — | — | US | disclosed |
| US-20120190820-A1 | FACILE AMIDE FORMATION VIA S-NITROSO THIOACID INTERMEDIATES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190820-A1 | FACILE AMIDE FORMATION VIA S-NITROSO THIOACID INTERMEDIATES | NAAA, TST, ASNS | CASP1 3493/4885GAA 2945/4885RAB9A 2323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.