Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.79 |
| ▸ | CTSL | P07711 | 3/20 | 0.75 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.67 |
| ▸ | P4HB | P07237 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.59 |
| ▸ | DPP4 | P27487 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499242 | 0.88 | NR1H4 (1.00) | NR1H4ABCG2P4HBCYP1A2CYP2D6 | |
| SCHEMBL611778 | 0.88 | NR1H4 (1.00) | NR1H4ABCG2P4HBCYP1A2CYP2D6 | |
| SCHEMBL29803121 | 0.88 | NR1H4 (1.00) | NR1H4ABCG2P4HBCYP1A2CYP2D6 | |
| SCHEMBL1225497 | 0.87 | CTSL (0.78) | NR1H4CTSLABCG2CYP1A2CYP2D6 | |
| SCHEMBL19474956 | 0.87 | CTSL (0.82) | CTSLABCG2CYP1A2CYP2D6ABCB1 | |
| SCHEMBL25193668 | 0.86 | CTSL (1.00) | CTSLABCG2P4HBCYP1A2CYP2D6 | |
| SCHEMBL30383744 | 0.86 | CTSL (1.00) | CTSLABCG2P4HBCYP1A2CYP2D6 | |
| SCHEMBL11937149 | 0.84 | P4HB (0.70) | NR1H4CTSLABCG2P4HBCYP1A2 | |
| SCHEMBL19508692 | 0.81 | CTSL (0.73) | CTSLABCG2CYP1A2CYP2D6ABCB1 | |
| SCHEMBL2992887 | 0.81 | P4HB (0.82) | NR1H4ABCG2P4HBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120277252-A1 | Antibacterial Agents and Methods of Use Thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2012-11-01 | — | — | US | disclosed |
| US-8227616-B2 | Cyanopyridine antibacterial agents and methods of use thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-07-24 | — | — | US | disclosed |
| US-20100261763-A1 | ANTIBACTERIAL AGENTS AND METHODS OF USE THEREOF | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-10-14 | — | — | US | disclosed |
| US-7737164-B2 | Cyanopyridine antibacterial agents | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-06-15 | — | — | US | disclosed |
| WO-2008016738-A2 | ANTIBACTERIAL AGENTS AND RELATED SCREENING METHODS USING SMALL MOLECULE MACROARRAYS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-02-07 | — | — | WO | disclosed |
| US-20080009528-A1 | ANTIBACTERIAL AGENTS AND RELATED SCREENING METHODS USING SMALL MOLECULE MACROARRAYS | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277252-A1 | Antibacterial Agents and Methods of Use Thereof | FDPS, ABCG2, DUT | NR1H4 2046/4885CTSL 1285/4885ABCG2 2/4885 |
| US-20080009528-A1 | ANTIBACTERIAL AGENTS AND RELATED SCREENING METHODS USING SMALL MOLECULE MACROARRAYS | PCNA, ABCG2, API5 | NR1H4 2815/4885CTSL 1530/4885ABCG2 2/4885 |
| US-20100261763-A1 | ANTIBACTERIAL AGENTS AND METHODS OF USE THEREOF | FDPS, CYP3A5, ABCG2 | NR1H4 2047/4885CTSL 1361/4885ABCG2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.