Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 3/20 | 0.76 |
| ▸ | CYP1B1 | Q16678 | 6/20 | 0.75 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.75 |
| ▸ | F3 | P13726 | 2/20 | 0.62 |
| ▸ | MAOB | P27338 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.57 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
| ▸ | CXCL12 | P48061 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11937146 | 0.90 | P4HB (0.67) | P4HBCYP1B1CYP1A1F3MAOB | |
| SCHEMBL25199747 | 0.87 | P4HB (1.00) | P4HBCYP1B1CYP1A1F3MAOB | |
| SCHEMBL25221835 | 0.87 | P4HB (1.00) | P4HBCYP1B1CYP1A1F3MAOB | |
| SCHEMBL25192715 | 0.86 | CYP1B1 (1.00) | P4HBCYP1B1CYP1A1F3MAOB | |
| SCHEMBL20244279 | 0.86 | CYP1B1 (1.00) | P4HBCYP1B1CYP1A1F3MAOB | |
| SCHEMBL3059923 | 0.84 | P4HB (0.63) | P4HBCYP1B1CYP1A1MAOBABCG2 | |
| SCHEMBL3059926 | 0.84 | P4HB (0.63) | P4HBCYP1B1CYP1A1MAOBABCG2 | |
| SCHEMBL25375955 | 0.82 | MAOB (0.79) | P4HBCYP1B1CYP1A1F3MAOB | |
| SCHEMBL4910956 | 0.80 | CYP1B1 (0.67) | P4HBCYP1B1CYP1A1MAOBCYP3A4 | |
| SCHEMBL2647645 | 0.79 | MEN1 (0.55) | P4HBCYP1B1CYP1A1MAOBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120277252-A1 | Antibacterial Agents and Methods of Use Thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2012-11-01 | — | — | US | disclosed |
| US-8227616-B2 | Cyanopyridine antibacterial agents and methods of use thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-07-24 | — | — | US | disclosed |
| US-20100261763-A1 | ANTIBACTERIAL AGENTS AND METHODS OF USE THEREOF | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-10-14 | — | — | US | disclosed |
| US-7737164-B2 | Cyanopyridine antibacterial agents | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-06-15 | — | — | US | disclosed |
| WO-2008016738-A2 | ANTIBACTERIAL AGENTS AND RELATED SCREENING METHODS USING SMALL MOLECULE MACROARRAYS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-02-07 | — | — | WO | disclosed |
| US-20080009528-A1 | ANTIBACTERIAL AGENTS AND RELATED SCREENING METHODS USING SMALL MOLECULE MACROARRAYS | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277252-A1 | Antibacterial Agents and Methods of Use Thereof | FDPS, ABCG2, DUT | P4HB 2360/4885CYP1B1 373/4885CYP1A1 634/4885 |
| US-20080009528-A1 | ANTIBACTERIAL AGENTS AND RELATED SCREENING METHODS USING SMALL MOLECULE MACROARRAYS | PCNA, ABCG2, API5 | P4HB 3790/4885CYP1B1 760/4885CYP1A1 1017/4885 |
| US-20100261763-A1 | ANTIBACTERIAL AGENTS AND METHODS OF USE THEREOF | FDPS, CYP3A5, ABCG2 | P4HB 2537/4885CYP1B1 324/4885CYP1A1 536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.