SCHEMBL25199747

SCHEMBL25199747

O=C(/C=C/c1cccc(C(F)(F)F)c1)c1ccc(O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P4HB P07237 6/20 1.00
MAOB P27338 7/20 0.72
CYP1B1 Q16678 3/20 0.69
CYP1A1 P04798 2/20 0.69
MAOA P21397 2/20 0.60
F3 P13726 2/20 0.60
MEN1 O00255 2/20 0.60
MAPT P10636 2/20 0.60
KMT2A Q03164 2/20 0.60
ALDH2 P05091 1/20 0.60
CYP3A4 P08684 1/20 0.60
HSPD1 P10809 1/20 0.60
CYP19A1 P11511 1/20 0.60
HSPE1 P61604 1/20 0.60
TDP1 Q9NUW8 1/20 0.60
RELA Q04206 1/20 0.60
KDM4E B2RXH2 1/20 0.57
LMNA P02545 1/20 0.56
HSP90AA1 P07900 1/20 0.56
PKM P14618 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25221835 1.00 P4HB (1.00) P4HBMAOBCYP1B1CYP1A1MAOA
SCHEMBL9779396 0.88 MAOB (0.83) P4HBMAOBCYP1B1CYP1A1MAOA
SCHEMBL3032561 0.88 MAOB (0.83) P4HBMAOBCYP1B1CYP1A1MAOA
SCHEMBL11942091 0.87 P4HB (0.78) P4HBMAOBCYP1B1CYP1A1MAOA
SCHEMBL15807364 0.87 P4HB (0.78) P4HBMAOBCYP1B1CYP1A1MAOA
SCHEMBL11941384 0.87 P4HB (0.76) P4HBMAOBCYP1B1CYP1A1MAOA
SCHEMBL2646706 0.86 P4HB (0.76) P4HBMAOBCYP1B1CYP1A1MAOA
SCHEMBL25211692 0.86 P4HB (0.75) P4HBMAOBCYP1B1CYP1A1MAPT
SCHEMBL25197853 0.86 P4HB (0.75) P4HBMAOBCYP1B1CYP1A1MAPT
SCHEMBL30384167 0.86 P4HB (0.75) P4HBMAOBCYP1B1CYP1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B P4HB 552/4885MAOB 1004/4885CYP1B1 230/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 P4HB 469/4885MAOB 2435/4885CYP1B1 1027/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 P4HB 469/4885MAOB 2435/4885CYP1B1 1027/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.