Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058465 | 0.88 | POLB (0.43) | POLBCYP3A4CYP2C19PPARGNCOA2 | |
| SCHEMBL14899753 | 0.85 | SMN1; SMN2 (0.48) | POLBCYP3A4CYP2C19PPARGNCOA2 | |
| SCHEMBL13776982 | 0.83 | DCTPP1 (0.59) | POLBCYP3A4CYP2C19PPARGNCOA2 | |
| SCHEMBL11945567 | 0.83 | POLB (0.49) | POLBCYP3A4CYP2C19PPARGNCOA2 | |
| SCHEMBL17058585 | 0.83 | POLB (0.42) | POLBCYP3A4CYP2C19PPARGNCOA2 | |
| SCHEMBL14899792 | 0.83 | HPGDS (0.40) | POLBCYP3A4CYP2C19PPARGNCOA2 | |
| SCHEMBL11945081 | 0.82 | ALDH1A1 (0.57) | POLBCYP3A4CYP2C19PPARGNCOA2 | |
| SCHEMBL17058537 | 0.81 | POLB (0.42) | POLBCYP3A4CYP2C19PPARGNCOA2 | |
| SCHEMBL11945565 | 0.81 | TP53 (0.47) | POLBCYP3A4CYP2C19PPARGNCOA2 | |
| SCHEMBL11945215 | 0.81 | MAPT (0.57) | POLBCYP3A4CYP2C19PPARGNCOA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232274-B2 | Pyridazinone derivatives useful as glucan synthase inhibitors | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| US-8232274-B2 | Pyridazinone derivatives useful as glucan synthase inhibitors | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-07-31 | — | — | US | disclosed |