Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20597599 | 0.80 | KDM4E (0.65) | MAPTKDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20597320 | 0.79 | MAPT (0.56) | MAPTKDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11965099 | 0.77 | ALDH1A1 (0.60) | MAPTKDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11965076 | 0.76 | KDM4E (0.63) | MAPTKDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20991197 | 0.71 | KDM4E (0.34) | MAPTKDM4EALDH1A1RAB9AGAA | |
| SCHEMBL11965098 | 0.71 | KDM4E (0.65) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL6121014 | 0.71 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2KMT2ACYP3A4 | |
| SCHEMBL9235523 | 0.70 | MAPT (0.50) | MAPTKDM4ESMN1; SMN2KMT2ACYP3A4 | |
| SCHEMBL13891899 | 0.70 | MAPT (0.52) | MAPTKDM4ESMN1; SMN2KMT2ACYP3A4 | |
| SCHEMBL68899 | 0.70 | MAPT (0.59) | MAPTKDM4ESMN1; SMN2KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120202794-A1 | COMPOUNDS | PHARMASSET, INC. (US) | 2012-08-09 | — | — | US | disclosed |
| US-20120202794-A1 | COMPOUNDS | PHARMASSET, INC. (US) | 2012-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202794-A1 | COMPOUNDS | HAVCR2, MAVS, GOT2 | MAPT 3932/4885KDM4E 4356/4885SMN1; SMN2 4051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.