Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.57 |
| ▸ | HTR1B | P28222 | 11/20 | 0.57 |
| ▸ | HTR1D | P28221 | 11/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | HTR2B | P41595 | 2/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.54 |
| ▸ | HTR3B | O95264 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR1E | P28566 | 1/20 | 0.54 |
| ▸ | HTR1F | P30939 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | HTR3A | P46098 | 1/20 | 0.54 |
| ▸ | HTR5A | P47898 | 1/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11258933 | 0.88 | HTR1D (0.56) | HTR1AHTR1BHTR1DCYP2D6CYP1A2 | |
| SCHEMBL12720711 | 0.88 | HTR1B (0.71) | HTR1AHTR1BHTR1DCYP2D6CYP1A2 | |
| Iodomethane SCHEMBL11265481 | 0.85 | HTR1A (0.53) | HTR1AHTR1BHTR1DCYP2D6CYP1A2 | |
| SCHEMBL23269429 | 0.85 | HTR1B (0.61) | HTR1AHTR1BHTR1DCYP2D6CYP1A2 | |
| SCHEMBL1196856 | 0.85 | HTR1D (0.56) | HTR1AHTR1BHTR1DCYP2D6CYP1A2 | |
| SCHEMBL1196012 | 0.84 | HTR2A (0.74) | HTR1AHTR1BHTR1DCYP2D6CYP1A2 | |
| SCHEMBL18311441 | 0.80 | HTR1B (0.56) | HTR1AHTR1BHTR1DCYP2D6CYP1A2 | |
| SCHEMBL8869870 | 0.80 | HTR1A (0.63) | HTR1AHTR1BHTR1DCYP2D6CYP1A2 | |
| SCHEMBL1195522 | 0.79 | HTR1D (0.49) | HTR1AHTR1BHTR1DCYP2D6CYP1A2 | |
| SCHEMBL14960988 | 0.79 | HTR1B (0.63) | HTR1AHTR1BHTR1DCYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862354-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2021-08-11 | — | — | EP | disclosed |
| EP-2824105-B1 | Indolopyridines as Eg5 kinesin modulators | 4SC AG (DE) | 2021-03-31 | — | — | EP | disclosed |
| EP-2824105-A1 | Indolopyridines as Eg5 kinesin modulators | 4SC AG (DE) | 2015-01-14 | — | — | EP | disclosed |
| US-8530493-B2 | Indolopyridines as Eg5 kinesin modulators | 4SC AG (DE) | 2013-09-10 | — | — | US | disclosed |
| US-20110027226-A1 | INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5) | 4SC AG (DE) | 2011-02-03 | — | — | US | disclosed |
| EP-2178875-A1 | INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5 ) | 4SC AG (DE) | 2010-04-28 | — | — | EP | disclosed |
| US-20090246169-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | NYCOMED GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
| US-20090233902-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2009-09-17 | — | — | US | disclosed |
| EP-2033962-A1 | Tetracyclic indolopyridines as EG5 inhibitors | 4SC AG (DE) | 2009-03-11 | — | — | EP | disclosed |
| WO-2009024613-A1 | TETRACYCLIC INDOLOPYRIDINES AS EG5 INHIBITORS | 4SC AG (DE) | 2009-02-26 | — | — | WO | disclosed |
| WO-2009024190-A1 | INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5 ) | 4SC AG (DE) | 2009-02-26 | — | — | WO | disclosed |
| EP-1996592-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | Nycomed GmbH (DE) | 2008-12-03 | — | — | EP | disclosed |
| EP-1994033-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007096395-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007096393-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2007-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110027226-A1 | INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5) | KIF5A, KIF5C, KIF5B | HTR1A 3485/4885HTR1B 3814/4885HTR1D 3384/4885 |
| US-20090233902-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | KIF5A, KIF5C, KIF5B | HTR1A 2100/4885HTR1B 2329/4885HTR1D 1900/4885 |
| US-20090246169-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | KIF5A, KIF5C, KIF5B | HTR1A 2100/4885HTR1B 2329/4885HTR1D 1900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.