SCHEMBL11972148

SCHEMBL11972148

N[C@H]1CCN(CCC(F)(F)F)C1

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 1/20 0.38
HRH2 P25021 2/20 0.35
HRH1 P35367 2/20 0.35
HRH3 Q9Y5N1 1/20 0.35
GNAI3 P08754 1/20 0.35
GNAO1 P09471 1/20 0.35
GNAI1 P63096 1/20 0.35
PGR P06401 1/20 0.33
ADORA2A P29274 1/20 0.31
PAX8 Q06710 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10002526 1.00 LTA4H (0.38) LTA4HHRH2HRH1HRH3GNAI3
SCHEMBL11971816 0.89 ADORA2A (0.37) LTA4HADORA2APAX8
SCHEMBL11972135 0.89 ADORA2A (0.37) LTA4HADORA2APAX8
SCHEMBL27438407 0.89 GNAI3 (0.41) LTA4HHRH2HRH1HRH3GNAI3
SCHEMBL4103985 0.88 GNAI3 (0.46) HRH2HRH1HRH3GNAI3GNAO1
Hydrochloric Acid SCHEMBL3430116 0.86 GNAO1 (0.48) HRH2HRH1HRH3GNAI3GNAO1
SCHEMBL1516424 0.83
SCHEMBL12927139 0.80 GNAI3 (0.39) LTA4HHRH2HRH1HRH3GNAI3
SCHEMBL20992134 0.79 KDM1A (0.33) LTA4HHRH2HRH1HRH3GNAI3
SCHEMBL22789404 0.79 KDM1A (0.33) LTA4HHRH2HRH1HRH3GNAI3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11746091-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2023-09-05 US disclosed
US-20230033510-A1 Compounds and Methods for Treatment of Visceral Pain ARENA PHARMACEUTICALS, INC. 2023-02-02 US disclosed
US-11214548-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2022-01-04 US disclosed
US-20210188781-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2021-06-24 US disclosed
US-20200078358-A1 Compounds and Methods for Treatment of Visceral Pain ARENA PHARMACEUTICALS, INC. 2020-03-12 US disclosed
US-20180354907-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2018-12-13 US disclosed
EP-3363788-A1 CANNABINOID RECEPTOR MODULATORS Arena Pharmaceuticals, Inc. (US) 2018-08-22 EP disclosed
CN-102596913-B Cannabinoid receptor modulators 艾尼纳制药公司 2016-11-09 CN disclosed
US-8778950-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2014-07-15 US disclosed
US-20120214766-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2012-08-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120214766-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, TRPV1 LTA4H 1320/4885HRH2 148/4885HRH1 108/4885
US-20200078358-A1 Compounds and Methods for Treatment of Visceral Pain VIP, FABP2, FABP6 LTA4H 478/4885HRH2 259/4885HRH1 1110/4885
US-20180354907-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, TRPV1 LTA4H 1320/4885HRH2 148/4885HRH1 108/4885
US-11746091-B2 Cannabinoid receptor modulators CNR1, CNR2, TRPV1 LTA4H 1320/4885HRH2 148/4885HRH1 108/4885
US-11214548-B2 Cannabinoid receptor modulators CNR1, CNR2, TRPV1 LTA4H 1320/4885HRH2 148/4885HRH1 108/4885
US-20230033510-A1 Compounds and Methods for Treatment of Visceral Pain VIP, FABP2, FABP6 LTA4H 478/4885HRH2 259/4885HRH1 1110/4885
US-20210188781-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, TRPV1 LTA4H 1320/4885HRH2 148/4885HRH1 108/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.