Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 10/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.35 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.35 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.35 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.35 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.35 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11979697 | 0.92 | TUBB4A (0.43) | CYP19A1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL11979704 | 0.86 | TUBB4A (0.43) | CYP19A1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL11979710 | 0.86 | ALDH1A1 (0.44) | CYP19A1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL11979699 | 0.86 | TUBB4A (0.44) | CYP19A1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL11979711 | 0.85 | PDE10A (0.39) | CYP19A1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL11979702 | 0.83 | PDE10A (0.39) | PDE10A | |
| SCHEMBL15975201 | 0.82 | PDE10A (0.38) | CYP19A1PDE10A | |
| SCHEMBL15975203 | 0.81 | PDE10A (0.38) | PDE10A | |
| SCHEMBL11979707 | 0.81 | PDE10A (0.43) | PDE10ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL11978295 | 0.80 | PDE10A (0.37) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| WO-2012102255-A1 | INDOLE DERIVATIVE AND PHARMACOLOGICALLY ACCEPTABLE SALT OF SAME | キッセイ薬品工業株式会社 (JP) | 2012-08-02 | — | — | WO | disclosed |