Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.35 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | HTR7 | P34969 | 2/20 | 0.31 |
| ▸ | HTR6 | P50406 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.31 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15975201 | 0.86 | PDE10A (0.38) | PDE10ADYRK1AGPR17MPOKDM4E | |
| SCHEMBL15975203 | 0.85 | PDE10A (0.38) | PDE10ADYRK1AGPR17MPOKDM4E | |
| SCHEMBL11979697 | 0.85 | TUBB4A (0.43) | PDE10AKDM4EALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL11979700 | 0.84 | PDE10A (0.36) | PDE10AMAPT | |
| SCHEMBL11978295 | 0.84 | PDE10A (0.37) | PDE10ADYRK1AGPR17MPOKDM4E | |
| SCHEMBL15975133 | 0.83 | PDE10A (0.37) | PDE10ADYRK1AGPR17MPOKDM4E | |
| SCHEMBL11979709 | 0.83 | CYP19A1 (0.48) | PDE10A | |
| SCHEMBL15975112 | 0.83 | MTNR1A (0.40) | PDE10ADYRK1AKDM4EALDH1A1CYP3A4 | |
| SCHEMBL11979699 | 0.81 | TUBB4A (0.44) | PDE10ANPC1 | |
| SCHEMBL11979710 | 0.81 | ALDH1A1 (0.44) | PDE10ADYRK1AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| WO-2012102255-A1 | INDOLE DERIVATIVE AND PHARMACOLOGICALLY ACCEPTABLE SALT OF SAME | キッセイ薬品工業株式会社 (JP) | 2012-08-02 | — | — | WO | disclosed |