Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | ACSS2 | Q9NR19 | 4/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8251906 | 0.92 | AGTR2 (0.39) | S1PR4ACSS2AGTR2DRD2DRD3 | |
| SCHEMBL16327762 | 0.88 | AGTR2 (0.35) | S1PR4ACSS2AGTR2DRD2DRD3 | |
| SCHEMBL8251311 | 0.79 | TLR8 (0.42) | S1PR4 | |
| SCHEMBL8252433 | 0.78 | S1PR4 (0.36) | S1PR4AGTR2AGTR1PDE2APDE10A | |
| SCHEMBL8247680 | 0.77 | TLR8 (0.42) | — | |
| SCHEMBL8242374 | 0.75 | AGTR2 (0.39) | AGTR2AGTR1ALOX5AP | |
| SCHEMBL8248706 | 0.75 | HTT (0.46) | AGTR2AGTR1MAPK1 | |
| SCHEMBL12884205 | 0.75 | CSF1R (0.41) | ACSS2ALOX5AP | |
| SCHEMBL8242381 | 0.74 | TLR7 (0.35) | S1PR4AGTR2AGTR1ALOX5AP | |
| SCHEMBL8249741 | 0.74 | F2 (0.36) | S1PR4AGTR2AGTR1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896450-B1 | 2-SUBSTITUTED BENZIMIDAZOLES | JANSSEN R & D IRELAND (IE) | 2012-08-15 | — | — | EP | disclosed |