Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.44 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.42 |
| ▸ | CDK9 | P50750 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2226003 | 0.81 | ERCC5 (0.63) | LOXL2ERCC5FEN1CDK2CDK5 | |
| SCHEMBL12875717 | 0.79 | HSD17B1 (0.51) | LOXL2HDAC6ALDH1A1ERCC5FEN1 | |
| SCHEMBL1199228 | 0.78 | ALDH1A1 (0.52) | HDAC6ALDH1A1ERCC5FEN1MEN1 | |
| SCHEMBL1764981 | 0.77 | ALDH1A1 (0.48) | HDAC6DYRK1ADYRK2ALDH1A1GAA | |
| SCHEMBL40156 | 0.77 | ADORA2A (0.49) | HDAC6DYRK1ADYRK2ALDH1A1GAA | |
| SCHEMBL12890279 | 0.77 | ALDH1A1 (0.46) | LOXL2HDAC6ALDH1A1GAAATM | |
| SCHEMBL18211804 | 0.75 | LOXL2 (0.47) | LOXL2ERCC5FEN1 | |
| SCHEMBL1198984 | 0.75 | SCN2A (0.47) | DYRK1ADYRK2ALDH1A1GAAATM | |
| SCHEMBL13018928 | 0.75 | ALDH1A1 (0.49) | HDAC6DYRK1ADYRK2ALDH1A1GAA | |
| SCHEMBL1198441 | 0.74 | MEN1 (0.50) | HDAC6ALDH1A1ERCC5FEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461348-B2 | Heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-06-11 | — | — | US | disclosed |
| US-8461348-B2 | Heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-06-11 | — | — | US | disclosed |
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-02-03 | — | — | US | disclosed |
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-02-03 | — | — | US | disclosed |
| EP-2264017-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-12-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | PDE3B, PDE5A, PDE2A | LOXL2 2797/4885HDAC6 2096/4885DYRK1A 4460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.