SCHEMBL2226003

SCHEMBL2226003

OCc1ncc(-c2ccccc2)s1

nearest known ligand 0.63

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ERCC5 P28715 1/20 0.63
FEN1 P39748 1/20 0.63
LOXL2 Q9Y4K0 3/20 0.58
KDR P35968 7/20 0.47
CCNE1 P24864 1/20 0.45
CDK2 P24941 1/20 0.45
CDK5 Q00535 1/20 0.45
LOXL3 P58215 1/20 0.43
ACP1 P24666 1/20 0.43
HTR7 P34969 1/20 0.43
GSTO1 P78417 1/20 0.43
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
HSD17B1 P14061 1/20 0.42
HSD17B2 P37059 1/20 0.42
SCD O00767 1/20 0.42
SLC5A2 P31639 1/20 0.42
PTPN1 P18031 1/20 0.41
NOTUM Q6P988 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12875717 0.83 HSD17B1 (0.51) ERCC5FEN1LOXL2KDRLOXL3
SCHEMBL28207097 0.81 LOXL2 (0.58) ERCC5FEN1LOXL2KDRCCNE1
SCHEMBL21812622 0.81 LOXL2 (0.84) ERCC5FEN1LOXL2KDRLOXL3
SCHEMBL9665362 0.81 LOXL2 (0.58) ERCC5FEN1LOXL2KDRCCNE1
SCHEMBL8830055 0.81 LOXL2 (0.58) ERCC5FEN1LOXL2KDRCCNE1
SCHEMBL2226631 0.81 LOXL2 (0.58) ERCC5FEN1LOXL2KDRCCNE1
SCHEMBL17014778 0.81 LOXL2 (0.58) ERCC5FEN1LOXL2KDRCCNE1
SCHEMBL1198760 0.81 LOXL2 (0.48) ERCC5FEN1LOXL2CDK2CDK5
SCHEMBL18211804 0.80 LOXL2 (0.47) ERCC5FEN1LOXL2KDRLOXL3
SCHEMBL330645 0.79 LOXL2 (0.57) ERCC5FEN1LOXL2KDRCCNE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3149190-A1 IDENTIFICATION OF NOVEL ANTI-PERSISTER ACTIVITY FOR BORRELIA BURGDORFERI The Johns Hopkins University (US) 2017-04-05 EP claimed
US-20170058314-A1 NOVEL METHODOLOGY FOR IDENTIFYING ANTI-PERSISTER ACTIVITY AND ANTIMICROBIAL SUSCEPTIBILITY FOR BORRELIA BURGDORFERI AND OTHER BACTERIA ZHANG YING (US) 2017-03-02 US claimed
WO-2015171225-A1 IDENTIFICATION OF NOVEL ANTI-PERSISTER ACTIVITY FOR BORRELIA BURGDORFERI THE JOHNS HOPKINS UNIVERSITY (US) 2015-11-12 WO claimed
EP-3321371-A1 NOVEL METHODS FOR RAPID DRUG SUSCEPTIBILITY TESTING AND DRUG SCREENS FOR GROWING AND NON-GROWING CELLS OF PROKARYOTIC AND EUKARYOTIC ORIGIN Zhang, Ying (US) 2018-05-16 EP disclosed
EP-3321371-A1 NOVEL METHODS FOR RAPID DRUG SUSCEPTIBILITY TESTING AND DRUG SCREENS FOR GROWING AND NON-GROWING CELLS OF PROKARYOTIC AND EUKARYOTIC ORIGIN Zhang, Ying (US) 2018-05-16 EP disclosed
EP-3149190-A1 IDENTIFICATION OF NOVEL ANTI-PERSISTER ACTIVITY FOR BORRELIA BURGDORFERI The Johns Hopkins University (US) 2017-04-05 EP disclosed
US-20170058314-A1 NOVEL METHODOLOGY FOR IDENTIFYING ANTI-PERSISTER ACTIVITY AND ANTIMICROBIAL SUSCEPTIBILITY FOR BORRELIA BURGDORFERI AND OTHER BACTERIA ZHANG YING (US) 2017-03-02 US disclosed
WO-2015171225-A1 IDENTIFICATION OF NOVEL ANTI-PERSISTER ACTIVITY FOR BORRELIA BURGDORFERI THE JOHNS HOPKINS UNIVERSITY (US) 2015-11-12 WO disclosed
EP-2533783-B1 COMPOUNDS AND METHODS for the inhibition of HDAC TEMPERO PHARMACEUTICALS INC (US) 2015-11-04 EP disclosed
EP-2533783-B1 COMPOUNDS AND METHODS for the inhibition of HDAC TEMPERO PHARMACEUTICALS INC (US) 2015-11-04 EP disclosed
US-20150038534-A1 COMPOUNDS AND METHODS TEMPERO PHARMACEUTICALS, INC. 2015-02-05 US disclosed
CN-103221047-A Compounds and methods TEMPERO PHARMACEUTICALS INC 2013-07-24 CN disclosed
US-20130059883-A1 COMPOUNDS AND METHODS TEMPERO PHARMACEUTICALS, INC. 2013-03-07 US disclosed
US-20130059883-A1 COMPOUNDS AND METHODS TEMPERO PHARMACEUTICALS, INC. 2013-03-07 US disclosed
US-20130059883-A1 COMPOUNDS AND METHODS TEMPERO PHARMACEUTICALS, INC. 2013-03-07 US disclosed
WO-2011088181-A9 COMPOUNDS AND METHODS TEMPERO PHARMACEUTICALS, INC. (US) 2013-01-31 WO disclosed
WO-2011088181-A9 COMPOUNDS AND METHODS TEMPERO PHARMACEUTICALS, INC. (US) 2013-01-31 WO disclosed
EP-2533783-A1 COMPOUNDS AND METHODS Tempero Pharmaceuticals, Inc. (US) 2012-12-19 EP disclosed
WO-2011088181-A1 COMPOUNDS AND METHODS TEMPERO PHARMACEUTICALS, INC. (US) 2011-07-21 WO disclosed
WO-2011088181-A1 COMPOUNDS AND METHODS TEMPERO PHARMACEUTICALS, INC. (US) 2011-07-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150038534-A1 COMPOUNDS AND METHODS XDH, LPXN, CCNY ERCC5 1318/4885FEN1 2698/4885LOXL2 156/4885
US-20130059883-A1 COMPOUNDS AND METHODS XDH, LPXN, CCNY ERCC5 1318/4885FEN1 2698/4885LOXL2 156/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.