Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12310822 | 0.89 | L3MBTL1 (0.57) | L3MBTL1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL18885189 | 0.84 | ALDH1A1 (0.53) | L3MBTL1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL17980699 | 0.82 | L3MBTL1 (0.54) | L3MBTL1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3410603 | 0.82 | L3MBTL1 (0.60) | L3MBTL1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL29048377 | 0.82 | ALDH1A1 (0.51) | L3MBTL1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL21847327 | 0.80 | ALDH1A1 (0.64) | L3MBTL1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4303760 | 0.80 | ALDH1A1 (0.52) | L3MBTL1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2270851 | 0.80 | ALDH1A1 (0.67) | L3MBTL1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8613491 | 0.80 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL17980670 | 0.78 | L3MBTL1 (0.50) | L3MBTL1ALDH1A1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846687-B2 | Pyrazine compounds as PI3 kinase inhibitors | NOVARTIS AG (CH) | 2014-09-30 | — | — | US | disclosed |
| US-8268834-B2 | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme | NOVARTIS AG (CH) | 2012-09-18 | — | — | US | disclosed |
| US-20120214800-A1 | Organic Compounds | NOVARTIS AG (CH) | 2012-08-23 | — | — | US | disclosed |
| US-20090239847-A1 | Organic compounds | NOVARTIS AG (CH) | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239847-A1 | Organic compounds | AR, TRPA1, IL33 | L3MBTL1 3906/4885ALDH1A1 150/4885CYP1A2 94/4885 |
| US-20120214800-A1 | Organic Compounds | AR, TRPA1, IL33 | L3MBTL1 3906/4885ALDH1A1 150/4885CYP1A2 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.