Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12003356 | 0.99 | NPY5R (0.54) | NPY5RALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL16857580 | 0.87 | SLC16A3 (0.51) | NPY5RALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL12003457 | 0.85 | ALDH1A1 (0.53) | NPY5RALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL12003459 | 0.85 | PDCD1 (0.49) | NPY5RALDH1A1KDM4EHPGDHTT | |
| SCHEMBL12018161 | 0.84 | ALDH1A1 (0.55) | NPY5RALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL6345119 | 0.84 | NPY5R (0.73) | NPY5RALDH1A1KDM4EHPGDLMNA | |
| Hydrochloric Acid SCHEMBL15609960 | 0.83 | ALDH1A1 (0.54) | NPY5RALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL6449553 | 0.83 | ALDH1A1 (0.61) | NPY5RALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL12003334 | 0.82 | ALDH1A1 (0.45) | NPY5RALDH1A1HPGDLMNASLC11A2 | |
| SCHEMBL12003407 | 0.82 | SMN1; SMN2 (0.47) | ALDH1A1KDM4ELMNAPDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9000176-B2 | Pyrazole derivatives, preparation method thereof, and composition for prevention and treatment of osteoporosis containing same | EWHA University—Industry Collaboration Foundation (KR) | 2015-04-07 | — | — | US | claimed |
| US-20140088152-A1 | COMPOSITION FOR PREVENTING AND TREATING CARDIOVASCULAR DISEASES, CONTAINING PYRAZOLE DERIVATIVE | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2014-03-27 | — | — | US | claimed |
| US-20140066404-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2014-03-06 | — | — | US | claimed |
| US-20120220550-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | EWHA UNIVERSITY- INDUSTRY COLLABORATION FOUNDATION (KR) | 2012-08-30 | — | — | US | claimed |
| US-9000176-B2 | Pyrazole derivatives, preparation method thereof, and composition for prevention and treatment of osteoporosis containing same | EWHA University—Industry Collaboration Foundation (KR) | 2015-04-07 | — | — | US | disclosed |
| US-20140088152-A1 | COMPOSITION FOR PREVENTING AND TREATING CARDIOVASCULAR DISEASES, CONTAINING PYRAZOLE DERIVATIVE | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2014-03-27 | — | — | US | disclosed |
| US-20140066404-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2014-03-06 | — | — | US | disclosed |
| US-8604210-B2 | Pyrazole derivatives, preparation method thereof, and composition for prevention and treatment of osteoporosis containing same | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2013-12-10 | — | — | US | disclosed |
| US-20120220550-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | EWHA UNIVERSITY- INDUSTRY COLLABORATION FOUNDATION (KR) | 2012-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220550-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | PTH1R, VDR, SOST | NPY5R 414/4885ALDH1A1 2869/4885KDM4E 1561/4885 |
| US-20140066404-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | PTH1R, VDR, SOST | NPY5R 414/4885ALDH1A1 2869/4885KDM4E 1561/4885 |
| US-20140088152-A1 | COMPOSITION FOR PREVENTING AND TREATING CARDIOVASCULAR DISEASES, CONTAINING PYRAZOLE DERIVATIVE | FABP3, PPARD, SIRT3 | NPY5R 1615/4885ALDH1A1 2049/4885KDM4E 2587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.