Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | USP14 | P54578 | 1/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12004522 | 0.96 | MAPT (0.42) | ALDH1A1LMNAMAPTNR1D1HTT | |
| SCHEMBL12018107 | 0.95 | LMNA (0.37) | ALDH1A1LMNAMAPTNR1D1HRH3 | |
| SCHEMBL17173855 | 0.91 | MAPT (0.39) | ALDH1A1LMNAMAPTNR1D1HTT | |
| SCHEMBL10316863 | 0.86 | HTR4 (0.36) | ALDH1A1LMNAHTTSMN1; SMN2NPC1 | |
| SCHEMBL16838295 | 0.84 | HTT (0.45) | ALDH1A1LMNAMAPTHRH3HTT | |
| SCHEMBL10317084 | 0.83 | TDP1 (0.46) | ALDH1A1LMNAMAPTHTTCCR2 | |
| SCHEMBL16837404 | 0.82 | HPGD (0.36) | ALDH1A1LMNAHTTKDM4ESMN1; SMN2 | |
| SCHEMBL5864578 | 0.82 | KCNJ1 (0.43) | ALDH1A1LMNAMAPTNR1D1HTT | |
| SCHEMBL12018106 | 0.82 | HTR4 (0.34) | ALDH1A1LMNAHTTSMN1; SMN2NPC1 | |
| SCHEMBL10316938 | 0.81 | PLA2G10 (0.39) | ALDH1A1LMNAHTTSMN1; SMN2CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2476683-B1 | NOVEL TETRA-AZA MACROCYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF | KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR) | 2019-04-03 | — | — | EP | disclosed |
| US-9353120-B2 | Tetraaza macrocyclic compound, preparation method thereof and use thereof | KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2016-05-31 | — | — | US | disclosed |
| US-20150291608-A1 | NOVEL TETRAAZA MACROCYCLIC COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF | KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2015-10-15 | — | — | US | disclosed |
| US-9061078-B2 | Tetraaza macrocyclic compound, preparation method thereof and use thereof | KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2015-06-23 | — | — | US | disclosed |
| US-20120219495-A1 | NOVEL TETRAAZA MACROCYCLIC COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF | KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2012-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291608-A1 | NOVEL TETRAAZA MACROCYCLIC COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF | TBCA, NBAS, BMP2 | ALDH1A1 3814/4885LMNA 1883/4885MAPT 481/4885 |
| US-20120219495-A1 | NOVEL TETRAAZA MACROCYCLIC COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF | TBCA, NBAS, BMP2 | ALDH1A1 3814/4885LMNA 1883/4885MAPT 481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.