Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31528300 | 0.79 | HRH3 (0.44) | HCAR3AOC3POLBTLR7HRH3 | |
| SCHEMBL12010810 | 0.77 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1POLBMAPTHRH3 | |
| SCHEMBL1320581 | 0.75 | HRH3 (0.47) | HCAR3AOC3POLBTLR7HRH3 | |
| SCHEMBL18291559 | 0.75 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1POLBMAPTLMNA | |
| SCHEMBL12010850 | 0.75 | CYP2C19 (0.46) | HCAR3SMN1; SMN2ALDH1A1POLBMAPT | |
| SCHEMBL12010833 | 0.74 | HRH3 (0.41) | HCAR3SMN1; SMN2ALDH1A1POLBMAPT | |
| SCHEMBL20037865 | 0.74 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1POLBMAPTLMNA | |
| SCHEMBL14007030 | 0.74 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1POLBMAPT | |
| SCHEMBL18291746 | 0.74 | GABRP (0.53) | SMN1; SMN2ALDH1A1POLBMAPTHDAC1 | |
| SCHEMBL20249193 | 0.72 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1POLBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252785-B2 | Aryl sulfonamides as bradykinin-B1-receptor antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-08-28 | — | — | US | disclosed |
| US-8252785-B2 | Aryl sulfonamides as bradykinin-B1-receptor antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-08-28 | — | — | US | disclosed |