Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.40 |
| ▸ | CCR9 | P51686 | 3/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20249222 | 0.86 | RIPK1 (0.39) | ALDH1A1SMN1; SMN2RIPK1CCR9KCNH2 | |
| SCHEMBL20255175 | 0.84 | PDE4B (0.36) | ALDH1A1SMN1; SMN2POLBMAPTRIPK1 | |
| SCHEMBL10223603 | 0.80 | CHRNB2 (0.44) | ALDH1A1CCR9LMNAKCNH2 | |
| SCHEMBL18291559 | 0.79 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2POLBMAPTRIPK1 | |
| SCHEMBL18291746 | 0.78 | GABRP (0.53) | ALDH1A1SMN1; SMN2POLBMAPTPDK2 | |
| SCHEMBL20037865 | 0.78 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2POLBMAPTRIPK1 | |
| SCHEMBL14007030 | 0.78 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2POLBMAPTRAB9A | |
| SCHEMBL12091528 | 0.77 | CCR9 (0.42) | ALDH1A1POLBCCR9KMT2A | |
| SCHEMBL20249183 | 0.75 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2MAPTCCR9GRIA2 | |
| SCHEMBL12040428 | 0.73 | CA2 (0.46) | CCR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | TEIJIN PHARMA LIMITED (JP) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | CDK4, CDK6, CDK16 | ALDH1A1 944/4885SMN1; SMN2 1690/4885POLB 1145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.