SCHEMBL12013

SCHEMBL12013

CCCCc1ccc(NS(=O)(=O)c2cccc(C(=O)N3CCN(c4ncccn4)CC3)c2)cc1

nearest known ligand 0.67

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.60
SMN1; SMN2 Q16637 4/20 0.60
LMNA P02545 2/20 0.60
GAA P10253 1/20 0.60
HTT P42858 2/20 0.59
ALDH1A1 P00352 4/20 0.56
KMT2A Q03164 2/20 0.56
MAPK1 P28482 1/20 0.56
MAPT P10636 1/20 0.56
PKM P14618 1/20 0.52
RAB9A P51151 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
HSP90AA1 P07900 1/20 0.49
HSP90AB1 P08238 1/20 0.49
SLC6A7 Q99884 1/20 0.48
HPGD P15428 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12597606 0.91 KMT2A (0.70) SMN1; SMN2LMNAGAAHTTALDH1A1
SCHEMBL14836 0.89 ALDH1A1 (0.53) KDM4ESMN1; SMN2LMNAGAAHTT
SCHEMBL19186836 0.87 KDM4E (0.58) KDM4ESMN1; SMN2LMNAHTTALDH1A1
SCHEMBL18973824 0.85 ALDH1A1 (0.53) LMNAALDH1A1KMT2APKMRAB9A
SCHEMBL1988297 0.84 KMT2A (0.47) KDM4ESMN1; SMN2LMNAGAAHTT
SCHEMBL12018 0.83 KMT2A (0.52) KDM4ESMN1; SMN2LMNAHTTALDH1A1
SCHEMBL14837 0.83 PKM (0.62) LMNAHTTALDH1A1KMT2AMAPK1
SCHEMBL1980459 0.81 LMNA (0.64) SMN1; SMN2LMNAGAAHTTALDH1A1
SCHEMBL1978914 0.81 NAMPT (0.51) SMN1; SMN2LMNAGAAHTTALDH1A1
SCHEMBL18516830 0.81 GAA (0.49) LMNAGAAALDH1A1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240071588-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS SERVIER PHARMACEUTICALS LLC (US) 2024-02-29 US disclosed
EP-3561077-B1 METHODS FOR CELL-PROLIFERATION-RELATED DISORDERS SERVIER LAB (FR) 2022-12-21 EP disclosed
US-20200281501-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS SERVIER PHARMACEUTICALS LLC 2020-09-10 US disclosed
US-10711314-B2 Methods for diagnosing IDH-mutant cell proliferation disorders AGIOS PHARMACEUTICALS, INC. (US) 2020-07-14 US disclosed
US-10610125-B2 Methods and compositions for cell-proliferation-related disorders AGIOS PHARMACEUTICALS, INC. (US) 2020-04-07 US disclosed
EP-3561077-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS Agios Pharmaceuticals, Inc. (US) 2019-10-30 EP disclosed
US-20190276894-A1 METHOD FOR TREATING CELL PROLIFERATION RELATED DISORDERS SERVIER PHARMACEUTICALS LLC 2019-09-12 US disclosed
US-9982309-B2 Method for treating cell proliferation related disorders AGIOS PHARMACEUTICALS, INC. (US) 2018-05-29 US disclosed
US-20170325708-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS AGIOS PHARMACEUTICALS, INC. (US) 2017-11-16 US disclosed
EP-2509600-B1 THERAPEUTICALLY ACTIVE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CHARACTERIZED AS HAVING AN IDH MUTATION AGIOS PHARMACEUTICALS INC (US) 2017-08-02 EP disclosed
US-20130183281-A1 METHODS AND COMPOSITONS FOR CELL-PROLIFERATION-RELATED DISORDERS SERVIER PHARMACEUTICALS LLC 2013-07-18 US disclosed
US-20130035329-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE SERVIER PHARMACEUTICALS LLC 2013-02-07 US disclosed
US-20130035329-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE SERVIER PHARMACEUTICALS LLC 2013-02-07 US disclosed
US-20130035329-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE SERVIER PHARMACEUTICALS LLC 2013-02-07 US disclosed
EP-2509600-A1 THERAPEUTICALLY ACTIVE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CHARACTERIZED AS HAVING AN IDH MUTATION Agios Pharmaceuticals, Inc. (US) 2012-10-17 EP disclosed
US-20120121515-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS SERVIER PHARMACEUTICALS LLC 2012-05-17 US disclosed
WO-2011072174-A1 THERAPEUTICALLY ACTIVE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CHARACTERIZED AS HAVING AN IDH MUTATION AGIOS PHARMACEUTICALS, INC. (US) 2011-06-16 WO disclosed
WO-2011072174-A1 THERAPEUTICALLY ACTIVE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CHARACTERIZED AS HAVING AN IDH MUTATION AGIOS PHARMACEUTICALS, INC. (US) 2011-06-16 WO disclosed
WO-2011050210-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS AGIOS PHARMACEUTICALS, INC. (US) 2011-04-28 WO disclosed
WO-2010105243-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS AGIOS PHARMACEUTICALS, INC. (US) 2010-09-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10711314-B2 Methods for diagnosing IDH-mutant cell proliferation disorders MKI67, IDH1, IDH3A KDM4E 1375/4885SMN1; SMN2 771/4885LMNA 3404/4885
US-10610125-B2 Methods and compositions for cell-proliferation-related disorders MKI67, BRCA1, CLN6 KDM4E 3913/4885SMN1; SMN2 18/4885LMNA 708/4885
US-20170325708-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS MKI67, BRCA1, CLN6 KDM4E 3913/4885SMN1; SMN2 18/4885LMNA 708/4885
US-20120121515-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS MKI67, BRCA1, CLN6 KDM4E 3913/4885SMN1; SMN2 18/4885LMNA 708/4885
US-20240071588-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS MKI67, BRCA1, CLN6 KDM4E 3913/4885SMN1; SMN2 18/4885LMNA 708/4885
US-20130183281-A1 METHODS AND COMPOSITONS FOR CELL-PROLIFERATION-RELATED DISORDERS IDH2, IDH1, MKI67 KDM4E 3190/4885SMN1; SMN2 234/4885LMNA 1485/4885
US-20130035329-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE MCL1, TP53, CD44 KDM4E 3489/4885SMN1; SMN2 474/4885LMNA 1011/4885
US-20200281501-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS MKI67, BRCA1, CLN6 KDM4E 3913/4885SMN1; SMN2 18/4885LMNA 708/4885
US-20190276894-A1 METHOD FOR TREATING CELL PROLIFERATION RELATED DISORDERS IDH2, IDH1, IDH3A KDM4E 2725/4885SMN1; SMN2 15/4885LMNA 1683/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.