Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.36 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070142 | 0.85 | KDM4E (0.40) | NPC1RAB9ATUBB4ATUBBTUBA3C | |
| SCHEMBL1202813 | 0.79 | MAPT (0.34) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1132463 | 0.79 | ACKR3 (0.31) | — | |
| SCHEMBL8360614 | 0.78 | NPC1 (0.41) | NPC1RAB9APDE4BTUBB4ATUBB | |
| SCHEMBL29929108 | 0.78 | NPC1 (0.40) | NPC1RAB9APDE4BTUBB4ATUBB | |
| SCHEMBL1201731 | 0.78 | NPC1 (0.40) | NPC1RAB9APDE4BTUBB4ATUBB | |
| SCHEMBL1202213 | 0.76 | TUBB4A (0.30) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4451221 | 0.76 | GABRP (0.58) | NPC1RAB9APDE4BTUBB4ATUBB | |
| SCHEMBL1201584 | 0.76 | — | — | |
| SCHEMBL28946311 | 0.75 | SYK (0.39) | NPC1RAB9APDE4BTUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756059-B1 | PROCESS FOR THE PRODUCTION OF CYCLIC DIKETONES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-05-07 | — | — | EP | disclosed |
| EP-1740524-B1 | PROCESS FOR THE PRODUCTION OF CYCLIC DIKETONES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-12-12 | — | — | EP | disclosed |
| US-7893270-B2 | Reacting 2,4,4-tribromobicyclo[3.2.1]oct-2-ene in chlorobenzene with acetonitrile and sulfuric acid to produce 4-bromo-bicyclo[3.2.1]oct-3-en-2-one | SYNGENTA CROP PROTECTION, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-7501544-B2 | Process for the production of cyclic diketones | SYNGENTA CROP PROTECTION, INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-20080139816-A1 | Process For the Production of Cyclic Diketones | SYNGENTA CROP PROTECTION, INC. (US) | 2008-06-12 | — | — | US | disclosed |
| US-20070232837-A1 | Process for the Production of Cyclic Diketones | SYNGENTA CROP PROTECTION, INC. (US) | 2007-10-04 | — | — | US | disclosed |
| EP-1756059-A1 | PROCESS FOR THE PRODUCTION OF CYCLIC DIKETONES | Syngeta Participations AG (CH) | 2007-02-28 | — | — | EP | disclosed |
| EP-1740524-A2 | PROCESS FOR THE PRODUCTION OF CYCLIC DIKETONES | Syngeta Participations AG (CH) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105718-A2 | PROCESS FOR THE PRODUCTION OF CYCLIC DIKETONES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-11-10 | — | — | WO | disclosed |
| WO-2005105745-A1 | PROCESS FOR THE PRODUCTION OF CYCLIC DIKETONES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232837-A1 | Process for the Production of Cyclic Diketones | CA9, ACAD9, F9 | NPC1 2126/4885RAB9A 437/4885PDE4B 2805/4885 |
| US-20080139816-A1 | Process For the Production of Cyclic Diketones | BCKDK, KCNJ1, KCNJ11 | NPC1 2165/4885RAB9A 3134/4885PDE4B 2537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.