SCHEMBL12018685

SCHEMBL12018685

CCC1CC=C(c2ccc(-c3ccc(OC)c(F)c3F)cc2F)CC1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CCNT1 O60563 7/20 0.38
CDK9 P50750 7/20 0.38
NAAA Q02083 3/20 0.34
HTR2C P28335 1/20 0.34
GRIN1 Q05586 1/20 0.34
GRIN2B Q13224 1/20 0.34
FPR2 P25090 1/20 0.33
PRKCZ Q05513 1/20 0.33
ALOX5AP P20292 1/20 0.33
FEN1 P39748 1/20 0.33
ESR2 Q92731 1/20 0.33
TDP2 O95551 1/20 0.32
PTGS2 P35354 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8937308 0.87 NAAA (0.36) CCNT1CDK9NAAAHTR2CGRIN1
SCHEMBL4549784 0.85 ALOX5AP (0.34) CCNT1CDK9NAAAHTR2CALOX5AP
SCHEMBL15870927 0.85 ESR2 (0.35) CCNT1CDK9ESR2
SCHEMBL8937652 0.85 NAAA (0.34) CCNT1CDK9NAAAHTR2CGRIN1
SCHEMBL8937869 0.84 MGLL (0.35) CCNT1CDK9NAAAHTR2CGRIN1
SCHEMBL13379000 0.84 CCNT1 (0.33) CCNT1CDK9NAAAHTR2C
SCHEMBL8935972 0.84 ESR2 (0.36) CCNT1CDK9NAAAGRIN1GRIN2B
SCHEMBL15381705 0.83 NAAA (0.35) CCNT1CDK9NAAAGRIN1GRIN2B
SCHEMBL13378241 0.82 CCNT1 (0.34) CCNT1CDK9HTR2CFPR2ALOX5AP
SCHEMBL8938369 0.82 CCNT1 (0.34) CCNT1CDK9NAAAHTR2CGRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2199362-B1 Liquid crystalline medium MERCK PATENT GMBH (DE) 2012-08-29 EP disclosed